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Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components

2021-07Artigo científico Acesso aberto
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dc.contributor.authorMartins, Susana G.
dc.contributor.authorZilhão, Rita
dc.contributor.authorThorsteinsdottir, Solveig
dc.contributor.authorCarlos, Ana Rita
dc.date.accessioned2021-07-29T17:48:48Z
dc.date.available2021-07-29T17:48:48Z
dc.date.issued2021-07
dc.description.abstractCells are subjected to endogenous [e.g., reactive oxygen species (ROS), replication stress] and exogenous insults (e.g., UV light, ionizing radiation, and certain chemicals), which can affect the synthesis and/or stability of different macromolecules required for cell and tissue function. Oxidative stress, caused by excess ROS, and DNA damage, triggered in response to different sources, are countered and resolved by specific mechanisms, allowing the normal physiological equilibrium of cells and tissues to be restored. One process that is affected by oxidative stress and DNA damage is extracellular matrix (ECM) remodeling, which is a continuous and highly controlled mechanism that allows tissues to readjust in reaction to different challenges. The crosstalk between oxidative stress/DNA damage and ECM remodeling is not unidirectional. Quite on the contrary, mutations in ECM genes have a strong impact on tissue homeostasis and are characterized by increased oxidative stress and potentially also accumulation of DNA damage. In this review, we will discuss how oxidative stress and DNA damage affect the expression and deposition of ECM molecules and conversely how mutations in genes encoding ECM components trigger accumulation of oxidative stress and DNA damage. Both situations hamper the reestablishment of cell and tissue homeostasis, with negative impacts on tissue and organ function, which can be a driver for severe pathological conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMartins SG, Zilhão R, Thorsteinsdóttir S and Carlos AR (2021) Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components. Front. Genet. 12:673002. doi: 10.3389/fgene.2021.673002pt_PT
dc.identifier.doi10.3389/fgene.2021.673002pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/49224
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationAssociation Française contre les Myopathies (AFM) Téléthon (contract no. 23049)pt_PT
dc.relationFCT, CEECIND/01589/2017pt_PT
dc.relationL’Oréal Portugal Medals of Honor for Women in Science 2019pt_PT
dc.relationFCT, PTDC/BTM-ORG/1383/2020pt_PT
dc.relationFCT, UIDB/00329/2020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleLinking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Componentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Geneticspt_PT
oaire.citation.volume12pt_PT
person.familyNameZilhão
person.familyNameThorsteinsdottir
person.familyNameCabral Martins Carlos
person.givenNameRita Maria Pulido Garcia Zilhão
person.givenNameSolveig
person.givenNameAna Rita
person.identifierM-3561-2013
person.identifierN-1137-2016
person.identifier.ciencia-idCF15-75FB-F490
person.identifier.ciencia-id6617-2213-FBDB
person.identifier.ciencia-id2E10-CE9E-ECE4
person.identifier.orcid0000-0002-1885-5432
person.identifier.orcid0000-0002-9018-3431
person.identifier.orcid0000-0002-6953-1163
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcfa9b9ca-8159-41ae-9857-f03e5502779a
relation.isAuthorOfPublication72f53b4c-978b-4ff0-b6bd-a042f259ab23
relation.isAuthorOfPublicatione0046f8d-b782-457b-be1d-4d12656b502a
relation.isAuthorOfPublication.latestForDiscovery72f53b4c-978b-4ff0-b6bd-a042f259ab23

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