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Erythropoietin Promotes Deleterious Cardiovascular Effects and Mortality Risk in a Rat Model of Chronic Sports Doping

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dc.contributor.authorPiloto, Nuno
dc.contributor.authorTeixeira, Helena M.
dc.contributor.authorTeixeira-Lemos, Edite
dc.contributor.authorParada, Belmiro
dc.contributor.authorGarrido, Patricia
dc.contributor.authorSereno, Jose
dc.contributor.authorPinto, Rui
dc.contributor.authorCarvalho, Lina
dc.contributor.authorCosta, Elisio
dc.contributor.authorBelo, Luis
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorTeixeira, Frederico
dc.contributor.authorReis, Flavio
dc.date.accessioned2015-12-30T10:18:19Z
dc.date.available2015-12-30T10:18:19Z
dc.date.issued2009
dc.description.abstractAthletes who abuse recombinant human erythropoietin (rhEPO) consider only the benefit to performance and usually ignore the potential short and long-term liabilities. Elevated haematocrit and dehydratation associated with intense exercise may reveal undetected cardiovascular risk, but the mechanisms underlying it remain to be fully explained. This study aimed to evaluate the cardiovascular effects of rhEPO in rats under chronic aerobic exercise. A ten week protocol was performed in four male Wistar rat groups: control-sedentary; rhEPO-50 IU kg(-1), 3 times/wk; exercised (EX)-swimming for 1 h, 3 times/wk; EX + rhEPO. One rat of the EX + rhEPO group suffered a sudden death episode during the week 8. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertrophy, sympathetic and serotonergic overactivation. The suddenly died rat's tissues presented brain with vascular congestion; left ventricular hypertrophy, together with a "cardiac-liver", suggesting the hypothesis of heart failure as cause of sudden death. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected RBC count increment, suggesting hyperviscosity, but also other serious deleterious cardiovascular and thromboembolic modifications, including mortality risk, which might be known and assumed by all sports authorities, including athletes and their physicians.
dc.formatapplication/pdf
dc.identifier.citationCARDIOVASCULAR TOXICOLOGY. - Vol. 9, n. 4 (DEC 2009), p. 201-210
dc.identifier.doihttp://dx.doi.org/10.1007/s12012-009-9054-2
dc.identifier.issn1530-7905
dc.identifier.urihttp://hdl.handle.net/10451/21528
dc.language.isoeng
dc.publisherHUMANA PRESS INC
dc.subjectCardiac & Cardiovascular Systems
dc.subjectToxicology
dc.titleErythropoietin Promotes Deleterious Cardiovascular Effects and Mortality Risk in a Rat Model of Chronic Sports Doping
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage210por
oaire.citation.startPage201por
oaire.citation.titleCARDIOVASCULAR TOXICOLOGYpor
oaire.citation.volumeVol. 9por
rcaap.rightsrestrictedAccess
rcaap.typearticle

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