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Cerebral malaria and the hemolysis/methemoglobin/heme hypothesis: shedding new light on an old disease

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dc.contributor.authorPamplona, Ana
dc.contributor.authorHanscheid, Thomas
dc.contributor.authorEpiphanio, Sabrina
dc.contributor.authorMota, Maria M.
dc.contributor.authorVigario, Ana Margarida
dc.date.accessioned2021-10-22T14:28:46Z
dc.date.available2021-10-22T14:28:46Z
dc.date.issued2009
dc.descriptionCopyright © 2008 Elsevier Ltd. All rights reserved.pt_PT
dc.description.abstractMalaria causes more than 1 million deaths every year with cerebral malaria (CM) being a major cause of death in Sub-Saharan African children. The nature of the malaria-associated pathogenesis is complex and multi-factorial. A unified hypothesis involving sequestration of infected red blood cells, systemic host inflammatory response and hemostasis dysfunction has been proposed to explain the genesis of CM. In this review, we discuss the role of hemolysis, methemoglobin and free heme in CM, brought to light by our recent studies in mice as well as by other studies in humans.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e Tecnologia, Portugal; Fellowships BPD/26633/2006 and BPD/31598/2006 to A.P. and S.E., respectively; Grant PTDC/SAU-MII/64125/2006 to A.P.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Biochem Cell Biol. 2009 Apr;41(4):711-716pt_PT
dc.identifier.doi10.1016/j.biocel.2008.09.020pt_PT
dc.identifier.eissn1878-5875
dc.identifier.issn1357-2725
dc.identifier.urihttp://hdl.handle.net/10451/49981
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCELLULAR AND MOLECULAR MECHANISMS OF ACTION OF HO-1 AND ITS END-PRODUCTS IN SEVERE MALARIA PATHOGENESIS
dc.relationTHE ROLE OF HO-1 AND CO IN MALARIA HEPATIC STAGE
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/the-international-journal-of-biochemistry-and-cell-biologypt_PT
dc.subjectCerebral malariapt_PT
dc.subjectHeme oxygenase-1pt_PT
dc.subjectCarbon monoxidept_PT
dc.subjectMethemoglobinpt_PT
dc.subjectFree hemept_PT
dc.titleCerebral malaria and the hemolysis/methemoglobin/heme hypothesis: shedding new light on an old diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BPD/26633/2006
oaire.awardNumberSFRH/BPD/31598/2006
oaire.awardNumberPTDC/SAU-MII/64125/2006
oaire.awardTitleCELLULAR AND MOLECULAR MECHANISMS OF ACTION OF HO-1 AND ITS END-PRODUCTS IN SEVERE MALARIA PATHOGENESIS
oaire.awardTitleTHE ROLE OF HO-1 AND CO IN MALARIA HEPATIC STAGE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F26633%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F31598%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-MII%2F64125%2F2006/PT
oaire.citation.endPage716pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage711pt_PT
oaire.citation.titleThe International Journal of Biochemistry & Cell Biologypt_PT
oaire.citation.volume41pt_PT
oaire.fundingStream3599-PPCDT
person.familyNamede Amarante Pamplona Dias dos Santos
person.familyNameHanscheid
person.familyNameEpiphanio
person.familyNameMota
person.familyNameVigário
person.givenNameAna Maria
person.givenNameThomas
person.givenNameSabrina
person.givenNameMaria Manuel
person.givenNameAna Margarida
person.identifier.ciencia-idB41A-AD97-42F1
person.identifier.ciencia-id4217-0969-297E
person.identifier.ciencia-idF911-B095-52FD
person.identifier.orcid0000-0001-5338-2768
person.identifier.orcid0000-0001-6353-9132
person.identifier.orcid0000-0001-6094-9750
person.identifier.orcid0000-0002-2858-1041
person.identifier.orcid0000-0001-5679-1196
person.identifier.ridC-7572-2012
person.identifier.scopus-author-id7004266513
person.identifier.scopus-author-id7801628078
person.identifier.scopus-author-id7102709816
person.identifier.scopus-author-id6603601164
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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