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Perspectives on directions and priorities for future preclinical studies in regenerative medicine

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dc.contributor.authorGrigorian Shamagian, Lilian
dc.contributor.authorMadonna, Rosalinda
dc.contributor.authorTaylor, Doris
dc.contributor.authorCliment, Andreu M.
dc.contributor.authorProsper, Felipe
dc.contributor.authorRosario, Luis
dc.contributor.authorBayes-Genis, Antoni
dc.contributor.authorFerdinandy, Péter
dc.contributor.authorFernández-Avilés, Francisco
dc.contributor.authorIzpisua Belmonte, Juan Carlos
dc.contributor.authorFuster, Valentin
dc.contributor.authorBolli, Roberto
dc.date.accessioned2020-11-02T14:59:04Z
dc.date.available2020-11-02T14:59:04Z
dc.date.issued2019
dc.description© American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.pt_PT
dc.description.abstractThe myocardium consists of numerous cell types embedded in organized layers of ECM (extracellular matrix) and requires an intricate network of blood and lymphatic vessels and nerves to provide nutrients and electrical coupling to the cells. Although much of the focus has been on cardiomyocytes, these cells make up <40% of cells within a healthy adult heart. Therefore, repairing or regenerating cardiac tissue by merely reconstituting cardiomyocytes is a simplistic and ineffective approach. In fact, when an injury occurs, cardiac tissue organization is disrupted at the level of the cells, the tissue architecture, and the coordinated interaction among the cells. Thus, reconstitution of a functional tissue must reestablish electrical and mechanical communication between cardiomyocytes and restore their surrounding environment. It is also essential to restore distinctive myocardial features, such as vascular patency and pump function. In this article, we review the current status, challenges, and future priorities in cardiac regenerative or reparative medicine. In the first part, we provide an overview of our current understanding of heart repair and comment on the main contributors and mechanisms involved in innate regeneration. A brief section is dedicated to the novel concept of rejuvenation or regeneration, which we think may impact future development in the field. The last section describes regenerative therapies, where the most advanced and disruptive strategies used for myocardial repair are discussed. Our recommendations for priority areas in studies of cardiac regeneration or repair are summarized in Tables 1 and 2 .pt_PT
dc.description.sponsorshipThe authors acknowledge the following sources: National Institutes of Health (NIH) Grants HL113530 and HL-78825; the Hungarian National Research, Development, and Innovation Office (OTKA KH_17 125570, NVKP 16-1-2016-0017 National Heart Program, and VEKOP-2.3.2-16-2016-00002) and the Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the Therapeutic Development thematic programme of the Semmelweis University; G. Harold and Leila Y. Mathers Charitable Foundation and Universidad Catolica San Antonio de Murcia (UCAM); the ISCIII and FEDER (TerCel DTS15/00095, PI16/01123, and RD16/0011/0005) and ERANET II Cofund under H2020 (Nanoreheart); the Ministerio de Economía, Industria y Competitividad (SAF2017-84324- C2-R), Fundació La MARATÓ de TV3 (201502, 201516), CIBER Cardiovascular (CB16/11/00403), and AdvanceCat 2014.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCirc Res. 2019 Mar 15;124(6):938-951pt_PT
dc.identifier.doi10.1161/CIRCRESAHA.118.313795pt_PT
dc.identifier.issn1524-4571
dc.identifier.urihttp://hdl.handle.net/10451/44741
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Heart Association, Inc.pt_PT
dc.relationHL113530pt_PT
dc.relationHL-78825pt_PT
dc.relationTerCel DTS15/00095pt_PT
dc.relationPI16/01123pt_PT
dc.relationOTKA KH_17 125570pt_PT
dc.relationNVKP 16-1-2016-0017pt_PT
dc.relationVEKOP-2.3.2-16-2016-00002pt_PT
dc.relationRD16/0011/0005pt_PT
dc.relationSAF2017-84324- C2-Rpt_PT
dc.relationCB16/11/00403pt_PT
dc.relation.publisherversionhttps://www.ahajournals.org/journal/respt_PT
dc.subjectPreclinical researchpt_PT
dc.subjectRegenerationpt_PT
dc.subjectRejuvenationpt_PT
dc.subjectRepairpt_PT
dc.titlePerspectives on directions and priorities for future preclinical studies in regenerative medicinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage951pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage938pt_PT
oaire.citation.titleCirculation Researchpt_PT
oaire.citation.volume124pt_PT
person.familyNameRosario
person.givenNameLuis
person.identifier.ciencia-id9B19-8F5B-7207
person.identifier.orcid0000-0003-0014-1543
person.identifier.ridB-2252-2013
person.identifier.scopus-author-id6602614908
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb0f83483-f787-4346-b2c1-e49a2d139790
relation.isAuthorOfPublication.latestForDiscoveryb0f83483-f787-4346-b2c1-e49a2d139790

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