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Animal tuberculosis: impact of disease heterogeneity in transmission, diagnosis, and control

2020-09Journal article Open access
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dc.contributor.authorPereira, André C.
dc.contributor.authorReis, Ana C.
dc.contributor.authorRamos, Beatriz
dc.contributor.authorCunha, Mónica V.
dc.date.accessioned2021-01-29T20:06:07Z
dc.date.available2021-12-01T01:30:25Z
dc.date.issued2020-09
dc.description.abstractAnimal tuberculosis (TB) in terrestrial mammals is mainly caused by Mycobacterium bovis. This pathogen is adapted to a wide range of host species, representing a threat to livestock, wildlife and human health. Disease heterogeneity is a hallmark of multi-host TB and a challenge for control. Drivers of animal TB heterogeneity are very diverse and may act at the level of the causative agent, the host species, the interface between mycobacteria and the host, community of hosts, the environment and even policy behind control programmes. In this paper, we examine the drivers that seem to contribute to this phenomenon. We begin by reviewing evidence accumulated to date supporting the consensus that a complex range of genetic, biological and socio-environmental factors contribute to the establishment and maintenance of animal TB, setting the grounds for heterogeneity. We then highlight the complex interplay between individual, species-specific and community protective factors with risk/maintenance variables that include animal movements and densities, co-infection and super-shedders. We finally consider how current interventions should seek to consider and explore heterogeneity in order to tackle potential limitations for diagnosis and control programmes, simultaneously increasing their efficacy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira AC, Reis AC, Ramos B, Cunha MV. Animal tuberculosis: Impact of disease heterogeneity in transmission, diagnosis and control. Transbound Emerg Dis. 17 2020;00:1–19. https://doi.org/10.1111/tbed.13539pt_PT
dc.identifier.doi10.1111/tbed.13539pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/46053
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationPOCI-01-0145-FEDER-029783pt_PT
dc.relationMyPATH- Insights into Mycobacterium tuberculosis complex PATHogenesis: assessing the benefit of confinement-induced biofilm strategies by comparative genomics
dc.relationUID/Multi/04046/2020pt_PT
dc.relationPDR2020-2024-049959pt_PT
dc.relationSystems epidemiology to devise new interventions for multi-host tuberculosis
dc.relationIncorporating the genomic signature of environmental Mycobacterium bovis into transmission models of animal TB under a phylodynamics conceptual framework
dc.titleAnimal tuberculosis: impact of disease heterogeneity in transmission, diagnosis, and controlpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMyPATH- Insights into Mycobacterium tuberculosis complex PATHogenesis: assessing the benefit of confinement-induced biofilm strategies by comparative genomics
oaire.awardTitleSystems epidemiology to devise new interventions for multi-host tuberculosis
oaire.awardTitleIncorporating the genomic signature of environmental Mycobacterium bovis into transmission models of animal TB under a phylodynamics conceptual framework
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT%2F117794%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/PD%2FBD%2F128031%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F136557%2F2018/PT
oaire.citation.titleTransboundary and Emerging Diseasespt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFARH
person.familyNameCunha
person.givenNameMonica V.
person.identifier348477
person.identifier.ciencia-id5616-E715-2F31
person.identifier.orcid0000-0003-0401-0276
person.identifier.ridD-5544-2011
person.identifier.scopus-author-id7102711216
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctPeríodo de embargo de 12 meses de acordo com a editora Wileypt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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