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Arthritis induces early bone high turnover, structural degradation and mechanical weakness

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dc.contributor.authorVidal, Bruno
dc.contributor.authorCascao, Rita
dc.contributor.authorVale, Ana Catarina
dc.contributor.authorCavaleiro, Inês
dc.contributor.authorVaz, Maria Fátima
dc.contributor.authorBrito, José Américo Almeida
dc.contributor.authorCanhao, Helena
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2022-03-14T16:47:30Z
dc.date.available2022-03-14T16:47:30Z
dc.date.issued2015
dc.descriptionCopyright: © 2015 Vidal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedpt_PT
dc.description.abstractBackground: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and degradation of bone biomechanical properties. The main goal of the present work was to study the effects of the first days of the inflammatory process on the microarchitecture and mechanical properties of bone. Methods: Twenty eight Wistar adjuvant-induced arthritis (AIA) rats were monitored during 22 days after disease induction for the inflammatory score, ankle perimeter and body weight. Healthy non-arthritic rats were used as controls for compar-ison. After 22 days of disease progression rats were sacrificed and bone samples were collected for histomorphometrical, energy dispersive X-ray spectroscopical analysis and 3-point bending. Blood samples were also collected for bone turnover markers. Results: AIA rats had an increased bone turnover (as inferred from increased P1NP and CTX1, p = 0.0010 and p = 0.0002, respectively) and this was paralleled by a decreased mineral content (calcium p = 0.0046 and phos-phorus p = 0.0046). Histomorphometry showed a lower trabecular thickness (p = 0.0002) and bone volume (p = 0.0003) and higher trabecular sepa-ration (p = 0.0009) in the arthritic group as compared with controls. In addition, bone mechanical tests showed evidence of fragility as depicted by diminished values of yield stress and ultimate fracture point (p = 0.0061 and p = 0.0279, re-spectively) in the arthritic group. Conclusions: We have shown in an AIA rat model that arthritis induc-es early bone high turnover, structural degradation, mineral loss and mechanical weak-ness.pt_PT
dc.description.sponsorshipThis work was supported by a grant SFRH/BD/81527/2011 from Fundação para a Ciência e a Tecnologia (FCT) and grant ECTS/Amgen Bone Biology Fellowship 2014 from European Calcified Tissue Society.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One . 2015 Jan 24;10(1):e0117100pt_PT
dc.identifier.doi10.1371/journal.pone.0117100pt_PT
dc.identifier.eissn1932-6203
dc.identifier.urihttp://hdl.handle.net/10451/51735
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLoSpt_PT
dc.relationHOW EARLY INFLAMMATORY EVENTS AFFECT BONE NANO-PROPERTIES AT THE ONSET OF RHEUMATOID ARTHRITIS
dc.relation.publisherversionhttps://journals.plos.org/plosone/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleArthritis induces early bone high turnover, structural degradation and mechanical weaknesspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/81527/2011
oaire.awardTitleHOW EARLY INFLAMMATORY EVENTS AFFECT BONE NANO-PROPERTIES AT THE ONSET OF RHEUMATOID ARTHRITIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F81527%2F2011/PT
oaire.citation.issue1pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume10pt_PT
person.familyNameCosta Vidal
person.familyNameCascão
person.familyNameCanhao
person.familyNameFonseca
person.givenNameBruno Miguel
person.givenNameRita
person.givenNameHelena
person.givenNameJoão
person.identifier.ciencia-id251C-3CD5-FB69
person.identifier.ciencia-idB616-D8BB-3CF2
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0003-2906-4705
person.identifier.orcid0000-0001-5533-9413
person.identifier.orcid0000-0002-3239-2809
person.identifier.orcid0000-0003-1432-3671
person.identifier.ridN-6675-2013
person.identifier.scopus-author-id35728434100
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id7101983519
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2dba0a1c-2d16-4430-9505-5ac8369b5c86
relation.isAuthorOfPublicationd315468f-594c-4234-be13-71fd82a135ab
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