Logo do repositório
 
Publicação

Changes of the phrenic nerve motor response in amyotrophic lateral sclerosis : longitudinal study

2009Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorPinto, Susana
dc.contributor.authorGeraldes, Ruth
dc.contributor.authorVaz, Nuno
dc.contributor.authorPinto, Anabela
dc.contributor.authorCarvalho, Mamede
dc.date.accessioned2021-05-31T14:40:42Z
dc.date.available2021-05-31T14:40:42Z
dc.date.issued2009
dc.descriptionCopyright © 2009 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.pt_PT
dc.description.abstractObjective: Phrenic nerve motor amplitude (Diaphr Ampl) is predictive of hypoventilation in amyotrophic lateral sclerosis (ALS). We aimed to evaluate its change over disease course and to correlate it to other measurements. Methods: Forty-nine unselected patients (35 men, 13 bulbar-onset, 56.5+/-8.9 years) with definitive or probable ALS were included. They were evaluated at entry (time 0) and 4-6 months (5.2+/-1.0) later (time 1) with: functional ALS rating scale (ALS-FRS) and respiratory subscore (ALS-FRSr); forced vital capacity (FVC); maximal inspiratory pressure (MIP); mean O(2) saturation overnight (SpO(2)mean); sniff maximal inspiratory pressure (SNIP); Diaphr Ampl and mean amplitude of the ulnar nerve response (ADM Ampl). Results: ALS-FRS, ALS-FRSr, Diaphr Ampl, FVC, SNIP, ADM Ampl (p<0.01) and SpO(2)mean (p<0.05) declined significantly. MIP did not change significantly (p=0.203). Coefficient of variation was similar for FVC, Diaphr Ampl, ADM Ampl and ALS-FRS but higher for SNIP. The percentage of change for Diaphr Ampl was significantly correlated to FVC and SNIP, but not to ADM Ampl or ALS-FRS. Conclusions: Diaphr Ampl decreased significantly in a short period of time and its change is correlated to other respiratory tests. This test can be useful in patients with marked facial weakness or uncooperative. Significance: Diaphr Ampl is useful to monitor respiratory function in ALS patients and can be applied in clinical trials.pt_PT
dc.description.sponsorshipThe first author has a grant from the “Fundação para a Ciência e a Tecnologia”, SFRH/BD/30714/2006. This work was supported by “Fundação para a Ciência e Tecnologia” – PIC/IC/82765/2007.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Neurophysiol. 2009 Dec;120(12):2082-2085pt_PT
dc.identifier.doi10.1016/j.clinph.2009.08.025pt_PT
dc.identifier.eissn1872-8952
dc.identifier.issn1388-2457
dc.identifier.urihttp://hdl.handle.net/10451/48263
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationESTUDOS CLÍNICOS E NEUROFISIOLÓGICOS PARA A COMPREENSÃO E A REABILITAÇÃO DA FADIGA RESPIRATÓRIA NA ELA
dc.relationRespiratory Rehabilitation in Amyotrophic Lateral Sclerosis: clinical and biochemical impact
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/clinical-neurophysiologypt_PT
dc.subjectALS-FRSpt_PT
dc.subjectAmyotrophic lateral sclerosispt_PT
dc.subjectPhrenic nerve motor responsept_PT
dc.subjectRespiratory function testspt_PT
dc.subjectUlnar nerve motor responsespt_PT
dc.titleChanges of the phrenic nerve motor response in amyotrophic lateral sclerosis : longitudinal studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/30714/2006
oaire.awardNumberPIC/IC/82765/2007
oaire.awardTitleESTUDOS CLÍNICOS E NEUROFISIOLÓGICOS PARA A COMPREENSÃO E A REABILITAÇÃO DA FADIGA RESPIRATÓRIA NA ELA
oaire.awardTitleRespiratory Rehabilitation in Amyotrophic Lateral Sclerosis: clinical and biochemical impact
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F30714%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5646-ICCMS/PIC%2FIC%2F82765%2F2007/PT
oaire.citation.endPage2085pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2082pt_PT
oaire.citation.titleClinical Neurophysiologypt_PT
oaire.citation.volume120pt_PT
oaire.fundingStream5646-ICCMS
person.familyNamePinto
person.familyNameGeraldes
person.familyNamePinto
person.familyNamede Carvalho
person.givenNameSusana
person.givenNameRuth
person.givenNameAnabela
person.givenNameMamede
person.identifier593760
person.identifier.ciencia-idD31B-E89C-CB94
person.identifier.orcid0000-0002-0727-5897
person.identifier.orcid0000-0001-5829-808X
person.identifier.orcid0000-0001-8139-6905
person.identifier.orcid0000-0001-7556-0158
person.identifier.ridL-8394-2019
person.identifier.scopus-author-id23397978500
person.identifier.scopus-author-id7402306398
person.identifier.scopus-author-id7101893769
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3fa09e71-c9b7-4536-a359-f7e3576dca09
relation.isAuthorOfPublication13995b84-e6d4-4b74-ba2d-29b5d5edc81d
relation.isAuthorOfPublicationac6330ee-bc35-45e5-9d9c-357de0c41f0b
relation.isAuthorOfPublicationdd7f55d4-c2b5-4fd2-9bd1-a9542a62f58f
relation.isAuthorOfPublication.latestForDiscoveryac6330ee-bc35-45e5-9d9c-357de0c41f0b
relation.isProjectOfPublicationdf9eebad-c74a-4573-ba20-ac62403d89c7
relation.isProjectOfPublicationc3bd31a7-3d0a-4d0a-b436-04c292e65d51
relation.isProjectOfPublication.latestForDiscoverydf9eebad-c74a-4573-ba20-ac62403d89c7

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Phrenic_nerve.pdf
Tamanho:
97.48 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais