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Unlocking the role of metabolic pathways in brain metastatic disease

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dc.contributor.authorPinto, Madalena
dc.contributor.authorViolante, Sara
dc.contributor.authorCascao, Rita
dc.contributor.authorFaria, Claudia
dc.date.accessioned2025-05-28T11:12:30Z
dc.date.available2025-05-28T11:12:30Z
dc.date.issued2025
dc.description© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe dissemination of malignant cells to the brain is a late-stage complication of cancer, leading to significant morbidity and mortality. Brain metastases (BM) affect 20-30% of cancer patients, primarily originating from lung cancer, breast cancer, and melanoma. Despite advances in molecular-targeted therapies, brain metastatic disease remains incurable, with a poor median survival of ≤12 months if left untreated. The lack of therapeutic efficacy is mainly attributed to the presence of the blood-brain barrier (BBB) and genetic differences between BM and their primary tumors. Previously published data have identified potential driver mutations of BM. However, the mechanisms underlying brain cancer dissemination remain unknown. Recent studies emphasize the pivotal role of metabolic adaptations in supporting the metastatic process, particularly in the nutrient-poor microenvironment characteristic of the brain. Understanding the interplay between metabolism and genetic alterations associated with brain metastatic disease could unveil novel therapeutic targets that are more effective in treating patients. This review focuses on relevant metabolic pathways in cancer, particularly brain cancer dissemination, while also presenting information on current preclinical models of BM, relevant clinical trials, and preclinical studies targeting metabolic reprogramming, providing an overview for advancing therapeutic strategies in BM.pt_PT
dc.description.sponsorshipM.P. was supported by a fellowship from Fundação para a Ciência e a Tecnologia (FCT, UI/BD/154739/2023). R.C. was supported by an individual employment contract from FCT (ref: 2023.09105.CEECIND/CP2857/CT0006; DOI: https://doi.org/10.54499/2023.09105.CEECIND/CP2857/CT0006). This work was funded by National Funds through the FCT, under the scope of the project 2022.08774.PTDC, Fundação Millennium BCP, Associação David Vaz, and private donations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCells. 2025 May 13;14(10):707pt_PT
dc.identifier.doi10.3390/cells14100707pt_PT
dc.identifier.eissn2073-4409
dc.identifier.urihttp://hdl.handle.net/10400.5/101076
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUI/BD/154739/2023pt_PT
dc.relation2023.09105.CEECIND/CP2857/CT0006pt_PT
dc.relation2022.08774.PTDCpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/cellspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBrain metastatic diseasept_PT
dc.subjectCancer metabolismpt_PT
dc.subjectMetabolic reprogrammingpt_PT
dc.subjectTherapeutic targetspt_PT
dc.titleUnlocking the role of metabolic pathways in brain metastatic diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.titleCellspt_PT
oaire.citation.volume14pt_PT
person.familyNameBravo de Moreira Pinto
person.familyNameViolante
person.familyNameCascão
person.familyNameFaria
person.givenNameMadalena Cristina
person.givenNameSara
person.givenNameRita
person.givenNameClaudia
person.identifier.ciencia-id0D17-41C0-3414
person.identifier.ciencia-idBC18-4380-9243
person.identifier.ciencia-idB616-D8BB-3CF2
person.identifier.ciencia-idAD1B-C408-B6A8
person.identifier.orcid0009-0007-1673-5676
person.identifier.orcid0000-0003-2124-5712
person.identifier.orcid0000-0001-5533-9413
person.identifier.orcid0000-0003-1259-9922
person.identifier.ridN-6675-2013
person.identifier.scopus-author-id35728434100
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3c3c477b-7802-4b9a-a58e-ffc25f5f95f3
relation.isAuthorOfPublication32288303-d4d5-405d-8ea4-5db01d369659
relation.isAuthorOfPublicationd315468f-594c-4234-be13-71fd82a135ab
relation.isAuthorOfPublication94ff2476-7001-4e97-9396-4a8716a7cbba
relation.isAuthorOfPublication.latestForDiscovery3c3c477b-7802-4b9a-a58e-ffc25f5f95f3

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