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Prognostic implications of left ventricular global longitudinal strain in patients with bicuspid aortic valve disease and preserved left ventricular ejection fraction

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dc.contributor.authorKong, William K F
dc.contributor.authorVollema, E. Mara
dc.contributor.authorPrevedello, Francesca
dc.contributor.authorPerry, Rebecca
dc.contributor.authorNg, Arnold C. T.
dc.contributor.authorPoh, Kian Keong
dc.contributor.authorAlmeida, Ana G.
dc.contributor.authorGonzález, Ariana
dc.contributor.authorShen, Mylène
dc.contributor.authorYeo, Tiong Cheng
dc.contributor.authorShanks, Miriam
dc.contributor.authorPopescu, Bogdan A.
dc.contributor.authorGalian Gay, Laura
dc.contributor.authorFijałkowski, Marcin
dc.contributor.authorLiang, Michael
dc.contributor.authorChen, Ruth W.
dc.contributor.authorAjmone Marsan, Nina
dc.contributor.authorSelvanayagam, Joseph
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorZamorano, Jose L.
dc.contributor.authorPibarot, Philippe
dc.contributor.authorEvangelista, Arturo
dc.contributor.authorDelgado, Victoria
dc.contributor.authorBax, Jeroen J.
dc.date.accessioned2019-10-30T11:18:49Z
dc.date.available2019-10-30T11:18:49Z
dc.date.issued2019
dc.descriptionPublished on behalf of the European Society of Cardiology. All rights reserved. © The Author(s), 2019. For permissions, please email: journals.permissions@oup.com.pt_PT
dc.description.abstractAims: In patients with bicuspid aortic valve (BAV) and preserved left ventricular (LV) ejection fraction (EF), the frequency of impaired LV global longitudinal strain (GLS) and its prognostic implications are unknown. The present study evaluated the proportion and prognostic value of impaired LV GLS in patients with BAV and preserved LVEF. Methods and results: Five hundred and thirteen patients (68% men; mean age 44 ± 18 years) with BAV and preserved LVEF (>50%) were divided into five groups according to the type of BAV dysfunction: (i) normal function BAV, (ii) mild aortic stenosis (AS) or aortic regurgitation (AR), (iii) ≥moderate isolated AS, (iv) ≥moderate isolated AR, and (v) ≥moderate mixed AS and AR. LV systolic dysfunction based on 2D speckle-tracking echocardiography was defined as a cut-off value of LVGLS (-13.6%). The primary outcome was aortic valve intervention or all-cause mortality. The proportion of patients with LVGLS ≤-13.6% was the highest in the normal BAV group (97%) and the lowest in the group with moderate and severe mixed AS and AR (79%). During a median follow-up of 10 years, 210 (41%) patients underwent aortic valve replacement and 17 (3%) died. Patients with preserved LV systolic function (LVGLS ≤ -13.6%) had significantly better event-free survival compared to those with impaired LV systolic function (LVGLS > -13.6%). LVGLS was independently associated with increased risk of events (mainly aortic valve replacement): hazard ratio 1.09; P < 0.001. Conclusion: Impaired LVGLS in BAV with preserved LVEF is not infrequent and was independently associated with increased risk of events (mainly aortic valve replacement events).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuropean Heart Journal - Cardiovascular Imaging (2019) 0, 1–9pt_PT
dc.identifier.doi10.1093/ehjci/jez252
dc.identifier.issn2047-2404
dc.identifier.urihttp://hdl.handle.net/10451/40013
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttps://academic.oup.com/ehjcimagingpt_PT
dc.subjectBicuspid aortic valvept_PT
dc.subjectGlobal longitudinal strainpt_PT
dc.subjectPrognosispt_PT
dc.titlePrognostic implications of left ventricular global longitudinal strain in patients with bicuspid aortic valve disease and preserved left ventricular ejection fractionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imagingpt_PT
person.familyNameAlmeida
person.familyNamePinto
person.givenNameAna Gomes de
person.givenNameFausto J.
person.identifier1308889
person.identifier.ciencia-id3610-3184-3042
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.orcid0000-0003-0360-4363
person.identifier.orcid0000-0002-8034-4529
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id55628683100
person.identifier.scopus-author-id7102740158
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7a34cb7e-96d7-426c-ac32-346c0c0fa68c
relation.isAuthorOfPublication5f44176f-69f5-482c-83cd-ab94425a6ec3
relation.isAuthorOfPublication.latestForDiscovery7a34cb7e-96d7-426c-ac32-346c0c0fa68c

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