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What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? A systematic review

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dc.contributor.authorTeixeira, Joana
dc.contributor.authorPereira, Inês
dc.contributor.authorCastanho, Miguel A. R. B.
dc.contributor.authorSimões Do Couto, Frederico
dc.date.accessioned2025-06-11T14:03:48Z
dc.date.available2025-06-11T14:03:48Z
dc.date.issued2025
dc.description© 2025 The Authors. Published by Elsevier B.V. on behalf of European Federation of Internal Medicine. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractCognitive impairments are frequently observed in patients with Alcohol Use Disorder (AUD). Thiamine deficiency is often found in AUD patients and has been suggested as a possible cause of cognitive impairments. While thiamine deficiency is not consistently present in all AUD patients with cognitive deficits, thiamine is traditionally prescribed to patients with AUD to treat or prevent cognitive impairment. To better understand the relationship between thiamine levels and cognitive impairments in AUD patients, we conducted a systematic literature review following the Cochrane guidelines and adhering to the PRISMA-P framework. Additionally, this review is registered in PROSPERO under the reference CRD42024522058. Our research question was: "what is the impact of thiamine deficiency on cognitive function in patients with AUD?". The studies included in this review assessed thiamine levels in AUD patients and found values at or above the threshold for many measures of thiamine deficiency. Despite baseline thiamine levels being above the cutoff for deficiency in these studies, many still identified a correlation between thiamine levels and cognitive function with lower thiamine levels associated with cognitive impairments in AUD patients. This review indicates that there is a relationship between thiamine levels and cognitive function in AUD patients, even in the absence of thiamine deficit. The cognitive domains particularly affected are visuospatial/executive ability, abstraction, attention, verbal fluency, and memory scores, notably delayed memory. Additionally, studies have demonstrated that thiamine supplementation in AUD patients, even in the absence of thiamine deficit, leads to improvements in cognitive function.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Intern Med. 2025 Apr:134:59-65pt_PT
dc.identifier.doi10.1016/j.ejim.2025.01.008pt_PT
dc.identifier.eissn1879-0828
dc.identifier.issn0953-6205
dc.identifier.urihttp://hdl.handle.net/10400.5/101493
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/european-journal-of-internal-medicinept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlcohol use disorderpt_PT
dc.subjectCognitionpt_PT
dc.subjectCognitive functionpt_PT
dc.subjectThiaminept_PT
dc.subjectThiamine deficiencypt_PT
dc.titleWhat is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? A systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage65pt_PT
oaire.citation.startPage59pt_PT
oaire.citation.titleEuropean Journal of Internal Medicinept_PT
oaire.citation.volume134pt_PT
person.familyNameTeixeira
person.familyNameCastanho
person.familyNameSimões do Couto
person.givenNameJoana
person.givenNameMiguel
person.givenNameFrederico
person.identifier.ciencia-idD117-0296-8086
person.identifier.orcid0000-0003-3211-7038
person.identifier.orcid0000-0001-7891-7562
person.identifier.orcid0000-0002-3916-2598
person.identifier.ridJ-9374-2017
person.identifier.scopus-author-id56605575600
person.identifier.scopus-author-id14621494400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione4240084-35cd-4522-afd9-020cab0cb1c4
relation.isAuthorOfPublicationf5e46f85-fabf-450a-9ee2-1c7b59410892
relation.isAuthorOfPublication88e58e2b-630a-44ef-a9c8-15a4c2f74fa7
relation.isAuthorOfPublication.latestForDiscovery88e58e2b-630a-44ef-a9c8-15a4c2f74fa7

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