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Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors : a case report and review of the literature

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dc.contributor.authorMousinho, Filipa
dc.contributor.authorSantos, Paula
dc.contributor.authorAzevedo, Ana
dc.contributor.authorPereira, José
dc.contributor.authorLemos, Raquel
dc.contributor.authorMatos, Sónia
dc.contributor.authorViana, João
dc.contributor.authorLima, Fernando
dc.date.accessioned2021-06-04T11:19:39Z
dc.date.available2021-06-04T11:19:39Z
dc.date.issued2018
dc.descriptionCopyright © 2018 Spandidos Publications. All rights reserved.pt_PT
dc.description.abstractPatients with a Philadelphia chromosome-negative myeloproliferative neoplasm may develop a lymphoproliferative disorder; however, the clinical and molecular determinants and the chronological onset of the two events remain unknown. We herein report the case of a 64-year-old man with concomitant diagnosis of high-risk essential thrombocythemia with evidence of a thrombotic event and high-count monoclonal B-cell lymphocytosis (high-count MBL). The patient harbored a JAK2V617F mutation and one of the most common genetic alterations found in chronic lymphocytic leukemia (CLL) (del 13q), which may represent a sign of disease progression. He was initiated on cytoreductive therapy with hydroxyurea 500 mg 3 times per week and hypocoagulation treatment, and is currently under regular surveillance of MBL without CLL criteria.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMol Clin Oncol. 2018 Sep;9(3):347-349pt_PT
dc.identifier.doi10.3892/mco.2018.1682pt_PT
dc.identifier.eissn2049-9469
dc.identifier.issn2049-9450
dc.identifier.urihttp://hdl.handle.net/10451/48325
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpandidos Publicationspt_PT
dc.relation.publisherversionhttps://www.spandidos-publications.com/mcopt_PT
dc.subjectMyeloproliferative neoplasmspt_PT
dc.subjectEssential thrombocythemiapt_PT
dc.subjectLymphoproliferative neoplasmspt_PT
dc.subjectMonoclonal B cell lymphocytosispt_PT
dc.subjectJAK2V617F mutationpt_PT
dc.subjectdel(13q)pt_PT
dc.titleConcomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors : a case report and review of the literaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage349pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage347pt_PT
oaire.citation.titleMolecular and Clinical Oncologypt_PT
oaire.citation.volume9pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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