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Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors : a case report and review of the literature
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Orientador(es)
Resumo(s)
Patients with a Philadelphia chromosome-negative myeloproliferative neoplasm may develop a lymphoproliferative disorder; however, the clinical and molecular determinants and the chronological onset of the two events remain unknown. We herein report the case of a 64-year-old man with concomitant diagnosis of high-risk essential thrombocythemia with evidence of a thrombotic event and high-count monoclonal B-cell lymphocytosis (high-count MBL). The patient harbored a JAK2V617F mutation and one of the most common genetic alterations found in chronic lymphocytic leukemia (CLL) (del 13q), which may represent a sign of disease progression. He was initiated on cytoreductive therapy with hydroxyurea 500 mg 3 times per week and hypocoagulation treatment, and is currently under regular surveillance of MBL without CLL criteria.
Descrição
Copyright © 2018 Spandidos Publications. All rights reserved.
Palavras-chave
Myeloproliferative neoplasms Essential thrombocythemia Lymphoproliferative neoplasms Monoclonal B cell lymphocytosis JAK2V617F mutation del(13q)
Contexto Educativo
Citação
Mol Clin Oncol. 2018 Sep;9(3):347-349
Editora
Spandidos Publications