Repository logo
 
Publication

Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells

2015Journal article Restricted access
Simple item page
dc.contributor.authorFreire, João M.
dc.contributor.authorGaspar, Diana
dc.contributor.authorVeiga, Ana Salomé
dc.contributor.authorCastanho, Miguel A. R. B.
dc.date.accessioned2016-04-19T13:23:36Z
dc.date.available2016-04-19T13:23:36Z
dc.date.issued2015
dc.description© 2015 European Peptide Society and John Wiley & Sons, Ltd.pt_PT
dc.description.abstractDespite the intensive study on the mechanism of action of membrane-activemolecules such as antimicrobial and anticancer peptides, most of the biophysical work has been performed using artificial model systems, mainly lipid vesicles. The use of these systems allows full control of the experimental parameters, and to obtain molecular-level detail on the action of peptides, the correlation with biological action is intangible. Recently, several biophysicalmethodologies have been translated to studies using bacterial and cancer cells. Here, we review biophysical studies on the mechanism of action of antimicrobial and anticancer peptides performed directly on cells. The data in these studies allow to correlate vesicle-based and cell-based studies and fill the vesicle-cell interdisciplinary gap.pt_PT
dc.description.sponsorshipProjects Ciência Sem Fronteiras PVE 171/2012 (CAPES, Brazil) and MSCA-RISE-2014-Nr644167 are acknowledged. D. Gaspar and J. Freire are recipients of fellowships SFRH/BPD/73500/2010 and SFRH/BD/70423/2010 from FCT, Portugal, respectively. A.S. Veiga acknowledges FCT, Portugal, for funding within the FCT Investigator Programme (IF/00803/2012).pt_PT
dc.identifier.citationJ. Pept. Sci. 2015; 21: 178–185pt_PT
dc.identifier.doi10.1002/psc.2741pt_PT
dc.identifier.issn1075-2617
dc.identifier.urihttp://hdl.handle.net/10451/23445
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationSTUDYING AND DEVELOPING ANTIMICROBIAL PEPTIDE HYDROGELS USED IN TISSUE REGENERATION
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1387pt_PT
dc.subjectCellpt_PT
dc.subjectVesiclept_PT
dc.subjectPeptidept_PT
dc.subjectMembranept_PT
dc.subjectBiophysicspt_PT
dc.subjectSpectroscopypt_PT
dc.subjectBacteriapt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectAnticancerpt_PT
dc.subjectLipidpt_PT
dc.titleShifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSTUDYING AND DEVELOPING ANTIMICROBIAL PEPTIDE HYDROGELS USED IN TISSUE REGENERATION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F73500%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F70423%2F2010/PT
oaire.citation.titleJournal of Peptide Sciencept_PT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication8aef3bd6-260c-4cad-afd0-15952a73f08e
relation.isProjectOfPublication1a004e63-0ace-4b41-bd0c-db90b919807e
relation.isProjectOfPublication.latestForDiscovery1a004e63-0ace-4b41-bd0c-db90b919807e

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
Anticancer_peptides.pdf
Size:
1.64 MB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
23445_FREE_Post-Print.pdf
Size:
2.12 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

IMM - Artigos em Revistas Internacionais