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Intraventricular thrombus formation and embolism in Takotsubo syndrome

2020Artigo científico Acesso restrito
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dc.contributor.authorDing, Katharina J.
dc.contributor.authorCammann, Victoria L.
dc.contributor.authorSzawan, Konrad A.
dc.contributor.authorStähli, Barbara E.
dc.contributor.authorWischnewsky, Manfred
dc.contributor.authorDi Vece, Davide
dc.contributor.authorCitro, Rodolfo
dc.contributor.authorJaguszewski, Milosz
dc.contributor.authorSeifert, Burkhardt
dc.contributor.authorSarcon, Annahita
dc.contributor.authorKnorr, Maike
dc.contributor.authorHeiner, Susanne
dc.contributor.authorGili, Sebastiano
dc.contributor.authorD’Ascenzo, Fabrizio
dc.contributor.authorNeuhaus, Michael
dc.contributor.authorNapp, L. Christian
dc.contributor.authorFranke, Jennifer
dc.contributor.authorNoutsias, Michel
dc.contributor.authorBurgdorf, Christof
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorKherad, Behrouz
dc.contributor.authorRajan, Lawrence
dc.contributor.authorMichels, Guido
dc.contributor.authorPfister, Roman
dc.contributor.authorCuneo, Alessandro
dc.contributor.authorJacobshagen, Claudius
dc.contributor.authorKarakas, Mahir
dc.contributor.authorPott, Alexander
dc.contributor.authorMeyer, Philippe
dc.contributor.authorArroja, Jose D.
dc.contributor.authorBanning, Adrian
dc.contributor.authorCuculi, Florim
dc.contributor.authorKobza, Richard
dc.contributor.authorFischer, Thomas A.
dc.contributor.authorVasankari, Tuija
dc.contributor.authorAiraksinen, K.E. Juhani
dc.contributor.authorPaolini, Carla
dc.contributor.authorBilato, Claudio
dc.contributor.authorCarrilho-Ferreira, Pedro
dc.contributor.authorOpolski, Grzegorz
dc.contributor.authorDworakowski, Rafal
dc.contributor.authorMacCarthy, Philip
dc.contributor.authorKaiser, Christoph
dc.contributor.authorOsswald, Stefan
dc.contributor.authorGaliuto, Leonarda
dc.contributor.authorDichtl, Wolfgang
dc.contributor.authorChan, Christina
dc.contributor.authorBridgman, Paul
dc.contributor.authorDelmas, Clément
dc.contributor.authorLairez, Olivier
dc.contributor.authorEl-Battrawy, Ibrahim
dc.contributor.authorAkin, Ibrahim
dc.contributor.authorGilyarova, Ekaterina
dc.contributor.authorShilova, Alexandra
dc.contributor.authorGilyarov, Mikhail
dc.contributor.authorKozel, Martin
dc.contributor.authorTousek, Petr
dc.contributor.authorWidimský, Petr
dc.contributor.authorWinchester, David E.
dc.contributor.authorGaluszka, Jan
dc.contributor.authorUkena, Christian
dc.contributor.authorHorowitz, John D.
dc.contributor.authorDi Mario, Carlo
dc.contributor.authorPrasad, Abhiram
dc.contributor.authorRihal, Charanjit S.
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorCrea, Filippo
dc.contributor.authorBorggrefe, Martin
dc.contributor.authorBraun-Dullaeus, Ruediger C.
dc.contributor.authorRottbauer, Wolfgang
dc.contributor.authorBauersachs, Johann
dc.contributor.authorKatus, Hugo A.
dc.contributor.authorHasenfuß, Gerd
dc.contributor.authorTschöpe, Carsten
dc.contributor.authorPieske, Burkert M.
dc.contributor.authorThiele, Holger
dc.contributor.authorSchunkert, Heribert
dc.contributor.authorBöhm, Michael
dc.contributor.authorFelix, Stephan B.
dc.contributor.authorMünzel, Thomas
dc.contributor.authorBax, Jeroen J.
dc.contributor.authorLüscher, Thomas F.
dc.contributor.authorRuschitzka, Frank
dc.contributor.authorGhadri, Jelena R.
dc.contributor.authorBossone, Eduardo
dc.contributor.authorTemplin, Christian
dc.date.accessioned2020-01-22T16:57:50Z
dc.date.available2020-01-22T16:57:50Z
dc.date.issued2020
dc.description© 2019 American Heart Association, Inc.pt_PT
dc.description.abstractObjective: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Additionally, factors associated with thrombus formation or embolism, as well as predictors for mortality, were identified. Approach and Results: TTS patients enrolled in the International Takotsubo Registry at 28 centers in Australia, Europe, and the United States were dichotomized according to the occurrence/absence of intraventricular thrombus or embolism. Patients with intraventricular thrombus or embolism were defined as the ThrombEmb group. Of 1676 TTS patients, 56 (3.3%) patients developed intraventricular thrombus and/or embolism following TTS diagnosis (median time interval, 2.0 days [range, 0–38 days]). Patients in the ThrombEmb group had a different clinical profile including lower left ventricular ejection fraction, higher prevalence of the apical type, elevated levels of troponin and inflammatory markers, and higher prevalence of vascular disease. In a Firth bias-reduced penalized-likelihood logistic regression model apical type, left ventricular ejection fraction ≤30%, previous vascular disease, and a white blood cell count on admission >10×103 cells/μL emerged as independent predictors for thrombus formation or embolism. Conclusions: Intraventricular thrombus or embolism occur in 3.3% of patients in the acute phase of TTS. A simple risk score including clinical parameters associated with intraventricular thrombus formation or embolism identifies patients at increased risk.pt_PT
dc.description.sponsorshipC. Templin has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Tani Research Programme and the Swiss Heart Foundation. The International Takotsubo Registry is supported by the Biss Davies Charitable Trust.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArterioscler Thromb Vasc Biol. 2020;40:279–287pt_PT
dc.identifier.doi10.1161/ATVBAHA.119.313491pt_PT
dc.identifier.eissn1524-4636
dc.identifier.issn1079-5642
dc.identifier.urihttp://hdl.handle.net/10451/41341
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Heart Associationpt_PT
dc.relation.publisherversionhttps://www.ahajournals.org/journal/atvbpt_PT
dc.subjectEmbolismpt_PT
dc.subjectOutcomept_PT
dc.subjectRisk scorept_PT
dc.subjectTakotsubo syndromept_PT
dc.subjectThrombuspt_PT
dc.titleIntraventricular thrombus formation and embolism in Takotsubo syndromept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage287pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage279pt_PT
oaire.citation.titleArteriosclerosis, Thrombosis, and Vascular Biologypt_PT
oaire.citation.volume40pt_PT
person.familyNameCarrilho-Ferreira
person.familyNamePinto
person.givenNamePedro
person.givenNameFausto J.
person.identifier1308889
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.orcid0000-0003-2008-1496
person.identifier.orcid0000-0002-8034-4529
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id7102740158
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationadd7664c-b062-4d11-be74-e8802d7c4258
relation.isAuthorOfPublication5f44176f-69f5-482c-83cd-ab94425a6ec3
relation.isAuthorOfPublication.latestForDiscoveryadd7664c-b062-4d11-be74-e8802d7c4258

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