Repository logo
 
Publication

Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents

2019Journal article Unknown
Simple item page
dc.contributor.authorVideira-Silva, Antonio
dc.contributor.authorAlbuquerque, Carolina
dc.contributor.authorFonseca, Helena
dc.date.accessioned2020-10-23T13:18:06Z
dc.date.available2020-10-23T13:18:06Z
dc.date.issued2019
dc.description© 2019 Annals of Pediatric Endocrinology & Metabolism. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractPurpose: Acanthosis nigricans (AN) is a hyperpigmented dermatosis associated with obesity and insulin resistance (IR). There is no consensus whether AN extension scoring offers added value to the clinical estimation of IR. In this study we aimed to assess and score AN using both a short and an extended version of the scale proposed by Burke et al. and analyze the relationships of both versions with hyperinsulinemia and IR. Methods: We analyzed data from 139 overweight adolescents (body mass index ≥85th percentile) aged 12–18 with (n=67) or without (n=72) AN who were followed at a pediatric obesity clinic. Results: Adolescents with AN had higher levels of insulin (d=0.56, P=0.003) and HOMA-IR (d=0.55, P=0.003) compared to those without. Neither the short nor the extended versions of AN scores explained either hyperinsulinemia (β=1.10, P=0.316; β=1.15, P=0.251) or IR (β=1.07, P=0.422; β=1.10, P=0.374). The presence of AN alone predicted hyperinsulinemia and the presence of IR in 7.3% (β=2.68, P=0.008) and 7.1% (β=2.59, P=0.009) of adolescents, respectively. Conclusion: Screening for AN at the neck and axilla is a noninvasive and cost-effective way to identify asymptomatic overweight adolescents with or at risk of developing IR.pt_PT
dc.description.sponsorshipAVS is supported by the Portuguese Foundation for Science and Technology (SFRH/BD/130193/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAnn Pediatr Endocrinol Metab 2019;24:99-103pt_PT
dc.identifier.doi10.6065/apem.2019.24.2.99pt_PT
dc.identifier.eissn2287-1292
dc.identifier.issn2287-1012
dc.identifier.urihttp://hdl.handle.net/10451/44649
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKorean Society of Pediatric Endocrinologypt_PT
dc.relationThe effect of a physical activity consultation in the management of adolescent overweight, including anthropometry, physical activity levels, cardiorespiratory fitness, and endothelial health
dc.relation.publisherversionhttps://e-apem.org/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAdolescentspt_PT
dc.subjectAcanthosis nigricanspt_PT
dc.subjectOverweightpt_PT
dc.subjectHyperinsulinemiapt_PT
dc.subjectInsulin resistancept_PT
dc.titleAcanthosis nigricans as a clinical marker of insulin resistance among overweight adolescentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe effect of a physical activity consultation in the management of adolescent overweight, including anthropometry, physical activity levels, cardiorespiratory fitness, and endothelial health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F130193%2F2017/PT
oaire.citation.endPage103pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage99pt_PT
oaire.citation.titleAnnals of Pediatric Endocrinology & Metabolismpt_PT
oaire.citation.volume24pt_PT
oaire.fundingStreamOE
person.familyNameVideira Silva
person.familyNameFonseca
person.givenNameAntonio
person.givenNameHelena
person.identifier.ciencia-idDD12-3E66-20BB
person.identifier.ciencia-id3F17-A0D4-D0C6
person.identifier.orcid0000-0002-8209-1676
person.identifier.orcid0000-0003-0565-1403
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3aa7bf17-683a-4293-b91c-6f31d56ab463
relation.isAuthorOfPublicationf4765445-af43-4a33-b056-4489e86ccc42
relation.isAuthorOfPublication.latestForDiscoveryf4765445-af43-4a33-b056-4489e86ccc42
relation.isProjectOfPublication267afb4d-710d-4088-ba34-e67a39970594
relation.isProjectOfPublication.latestForDiscovery267afb4d-710d-4088-ba34-e67a39970594

Files

Collections

FM-CUP-Artigos em Revistas Internacionais
Load more