Logo do repositório
 
Publicação

Snake venom cathelicidins as natural antimicrobial peptides

2019Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorde Barros, Elizângela
dc.contributor.authorGonçalves, Regina M.
dc.contributor.authorCardoso, Marlon H.
dc.contributor.authorSantos, Nuno C.
dc.contributor.authorFranco, Octávio L.
dc.contributor.authorCândido, Elizabete S.
dc.date.accessioned2022-04-13T15:55:17Z
dc.date.available2022-04-13T15:55:17Z
dc.date.issued2019
dc.descriptionCopyright © 2019 de Barros, Gonçalves, Cardoso, Santos, Franco and Cândido. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractBioactive small molecules isolated from animals, plants, fungi and bacteria, including natural antimicrobial peptides, have shown great therapeutic potential worldwide. Among these peptides, snake venom cathelicidins are being widely exploited, because the variation in the composition of the venom reflects a range of biological activities that may be of biotechnological interest. Cathelicidins are short, cationic, and amphipathic molecules. They play an important role in host defense against microbial infections. We are currently facing a strong limitation on pharmacological interventions for infection control, which has become increasingly complex due to the lack of effective therapeutic options. In this review, we will focus on natural snake venom cathelicidins as promising candidates for the development of new antibacterial agents to fight antibiotic-resistant bacteria. We will highlight their antibacterial and antibiofilm activities, mechanism of action, and modulation of the innate immune response.pt_PT
dc.description.sponsorshipThis work was supported by Conselho Nacional de Pesquisa (CNPq); Coordenação de Aperfeiçoamento Pessoal de Nível Superior (CAPES); Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF) and Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT), Brazil.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Pharmacol. 2019 Nov 29;10:1415pt_PT
dc.identifier.doi10.3389/fphar.2019.01415pt_PT
dc.identifier.eissn1663-9812
dc.identifier.urihttp://hdl.handle.net/10451/52341
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/pharmacology#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial peptidespt_PT
dc.subjectCathelicidinspt_PT
dc.subjectHost-defense peptidespt_PT
dc.subjectNatural peptidespt_PT
dc.subjectSnake venompt_PT
dc.titleSnake venom cathelicidins as natural antimicrobial peptidespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Pharmacologypt_PT
oaire.citation.volume10pt_PT
person.familyNameSantos
person.givenNameNuno
person.identifier.ciencia-idCD13-5E3A-A3C5
person.identifier.orcid0000-0002-0580-0475
person.identifier.ridN-7248-2013
person.identifier.scopus-author-id55940818300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4656d912-5a2d-4c80-8921-2bcba3aa441a
relation.isAuthorOfPublication.latestForDiscovery4656d912-5a2d-4c80-8921-2bcba3aa441a

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Snake_venom.pdf
Tamanho:
1.41 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais