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Acute symptomatic seizures in cerebral venous thrombosis

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dc.contributor.authorLindgren, Erik
dc.contributor.authorSilvis, Suzanne M.
dc.contributor.authorHiltunen, Sini
dc.contributor.authorHeldner, Mirjam R.
dc.contributor.authorSerrano, Fabiola
dc.contributor.authorde Scisco, Michele
dc.contributor.authorZelano, Johan
dc.contributor.authorZuurbier, Susanna M.
dc.contributor.authorSánchez van Kammen, Mayte
dc.contributor.authorMansour, Maryam
dc.contributor.authorde Sousa, Diana Aguiar
dc.contributor.authorPenas, Sara
dc.contributor.authorAl-Asady, Saleem
dc.contributor.authorEkizoglu, Esme
dc.contributor.authorRedfors, Petra
dc.contributor.authorAhmed, Awet
dc.contributor.authorYesilot, Nilufer
dc.contributor.authorGhiasian, Masoud
dc.contributor.authorBarboza, Miguel A.
dc.contributor.authorArnao, Valencia
dc.contributor.authorAridon, Paolo
dc.contributor.authorPunter, Martin N.M.
dc.contributor.authorFerro, José
dc.contributor.authorKleinig, Timothy
dc.contributor.authorArauz, Antonio
dc.contributor.authorTatlisumak, Turgut
dc.contributor.authorArnold, Marcel
dc.contributor.authorPutaala, Jukka
dc.contributor.authorCoutinho, Jonathan M.
dc.contributor.authorJood, Katarina
dc.date.accessioned2021-01-04T18:23:06Z
dc.date.available2021-01-04T18:23:06Z
dc.date.issued2020
dc.description© 2020 American Academy of Neurologypt_PT
dc.description.abstractObjective: To identify characteristics, predictors, and outcomes of acute symptomatic seizures (ASS) in cerebral venous thrombosis (CVT), we investigated 1,281 consecutive adult patients with CVT included from 12 hospitals within the International CVT Consortium. Methods: We defined ASS as any seizure between symptom onset and 7 days after diagnosis of CVT. We stratified ASS into prediagnosis and solely postdiagnosis ASS. Status epilepticus (SE) was also analyzed separately. We analyzed predictors for ASS and the association between ASS and clinical outcome (modified Rankin Scale) with multivariable logistic regression. Results: Of 1,281 eligible patients, 441 (34%) had ASS. Baseline predictors for ASS were intracerebral hemorrhage (ICH; adjusted odds ratio [aOR] 4.1, 95% confidence interval [CI] 3.0-5.5), cerebral edema/infarction without ICH (aOR 2.8, 95% CI 2.0-4.0), cortical vein thrombosis (aOR 2.1, 95% CI 1.5-2.9), superior sagittal sinus thrombosis (aOR 2.0, 95% CI 1.5-2.6), focal neurologic deficit (aOR 1.9, 95% CI 1.4-2.6), sulcal subarachnoid hemorrhage (aOR 1.6, 95% CI 1.1-2.5), and female-specific risk factors (aOR 1.5, 95% CI 1.1-2.1). Ninety-three (7%) patients had solely postdiagnosis ASS, best predicted by cortical vein thrombosis (positive/negative predictive value 22%/92%). Eighty (6%) patients had SE, independently predicted by ICH, focal neurologic deficits, and cerebral edema/infarction. Neither ASS nor SE was independently associated with outcome. Conclusion: ASS occurred in one-third of patients with CVT and was associated with brain parenchymal lesions and thrombosis of the superficial system. In the absence of prediagnosis ASS, no subgroup was identified with sufficient risk of postdiagnosis ASS to justify prophylactic antiepileptic drug treatment. We found no association between ASS and outcome.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeurology. 2020 Sep 22;95(12):e1706-e1715pt_PT
dc.identifier.doi10.1212/WNL.0000000000010577pt_PT
dc.identifier.eissn1526-632X
dc.identifier.issn0028-3878
dc.identifier.urihttp://hdl.handle.net/10451/45651
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Academy of Neurologypt_PT
dc.relation.publisherversionhttps://n.neurology.org/pt_PT
dc.titleAcute symptomatic seizures in cerebral venous thrombosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPagee1715pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPagee1706pt_PT
oaire.citation.titleNeurologypt_PT
oaire.citation.volume95pt_PT
person.familyNameAguiar de Sousa
person.familyNameMorão Cabral Ferro
person.givenNameDiana
person.givenNameJosé Manuel
person.identifier574112
person.identifier.ciencia-id571C-121A-5CCB
person.identifier.ciencia-id6F16-7E25-7AAF
person.identifier.orcid0000-0002-6702-7924
person.identifier.orcid0000-0002-2343-9097
person.identifier.ridJ-4105-2013
person.identifier.scopus-author-id55781226000
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1d984575-dd95-4ca1-9092-bf6f9914ba63
relation.isAuthorOfPublication9a568ce6-d218-44fc-982c-0ffe7bffc197
relation.isAuthorOfPublication.latestForDiscovery9a568ce6-d218-44fc-982c-0ffe7bffc197

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