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Algorithm to assess the presence of Aspergillus fumigatus resistant strains : the case of Norwegian sawmills

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dc.contributor.authorViegas, Carla
dc.contributor.authorAlmeida, Beatriz
dc.contributor.authorCaetano, Liliana Aranha
dc.contributor.authorAfanou, Anani
dc.contributor.authorStraumfors, Anne
dc.contributor.authorVeríssimo, Cristina
dc.contributor.authorGonçalves, Paulo
dc.contributor.authorSabino, Raquel Filipa Pinheiro
dc.date.accessioned2020-09-07T13:31:40Z
dc.date.available2020-09-07T13:31:40Z
dc.date.issued2020
dc.description© 2020 Informa UK Limited, trading as Taylor & Francis Group.pt_PT
dc.description.abstractAssociation between selection pressure caused by the use of azole fungicides in sawmills and the development of fungal resistance has been described. The aim of this study was to implement an algorithm to assess the presence of Aspergillus section Fumigati resistant strains in sawmills. Eighty-six full-shift inhalable dust samples were collected from eleven industrial sawmills in Norway. Different culture media were used and molecular identification to species level in Aspergillus section Fumigati was done by calmodulin sequencing and TR34/L98H and TR46/Y121F/T289A mutations were screened by real-time PCR assay and confirmed by cyp51A sequencing. Six Fumigati isolates were identified as A. fumigatus sensu stricto and two of these grew on azole-supplemented media and were further analyzed by real-time PCR. One was confirmed to be a TR34/L98H mutant. The obtained results reinforce the need to assess the presence of A. fumigatus sensu stricto resistant isolates at other workplaces with fungicide pressure.pt_PT
dc.description.sponsorshipThis work was supported by the Research council of Norway [218232/H20]; Instituto Politécnico de Lisboa [IPL/ 2018/WasteFRPD_ESTeSL]; Fundação para Ciência e Tecnologia [02/SAICT/2016 – Project nº 23222]. H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/ 2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInternational Journal of Environmental Health Research, 19 Aug 2020pt_PT
dc.identifier.doi10.1080/09603123.2020.1810210pt_PT
dc.identifier.eissn1369-1619
dc.identifier.issn0960-3123
dc.identifier.urihttp://hdl.handle.net/10451/44315
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationIPL/2018/WasteFRPD_ESTeSLpt_PT
dc.relation02/SAICT/2016pt_PT
dc.relationHealth and Technology Research Center
dc.relation.publisherversionhttps://www.tandfonline.com/toc/cije20/currentpt_PT
dc.subjectSection Fumigatipt_PT
dc.subjectAspergillus fumigatus resistant isolatespt_PT
dc.subjectOccupational exposurept_PT
dc.subjectCross-resistancept_PT
dc.subjectFungicide pressurept_PT
dc.titleAlgorithm to assess the presence of Aspergillus fumigatus resistant strains : the case of Norwegian sawmillspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth and Technology Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05608%2F2020/PT
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Journal of Environmental Health Researchpt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameViegas
person.familyNameTavares de Almeida
person.familyNameCaetano
person.familyNameVeríssimo
person.familyNameSabino
person.givenNameCarla
person.givenNameBeatriz Luciana
person.givenNameLiliana Aranha
person.givenNameCristina
person.givenNameRaquel Filipa Pinheiro
person.identifier166296
person.identifier1411004
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.ciencia-idA916-EA01-5B11
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.ciencia-id3F16-C108-8FFE
person.identifier.orcid0000-0002-1545-6479
person.identifier.orcid0000-0002-2533-1397
person.identifier.orcid0000-0003-1496-2609
person.identifier.orcid0000-0002-1169-252X
person.identifier.orcid0000-0001-6585-7775
person.identifier.ridO-4292-2016
person.identifier.scopus-author-id55490838100
person.identifier.scopus-author-id36615880000
person.identifier.scopus-author-id35796067600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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