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Publication
Biodegradation of acrylic based resins: A review
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Advisor(s)
Abstract(s)
Objectives. The development of different types of materials with application in dentistry is
an area of intense growth and research, due to its importance in oral health. Among the
different materials there are the acrylic based resins that have been extensively used either
in restorations or in dentures. The objective of this manuscript was to review the acrylic
based resins biodegradation phenomena. Specific attention was given to the causes and
consequences of materials degradation under the oral environment.
Data and sources. Information from scientific full papers, reviews or abstracts published from
1963 to datewere included in the review. Published materialwas searched in dental literature
using general and specialist databases, like the PubMED database.
Study selection. Published studies regarding the description of biodegradation mechanisms,
in vitro and in vivo release experiments and cell based studies conducted on acrylic based
resins or their components were evaluated. Studies related to the effect of biodegradation
on the physical and mechanical properties of the materials were also analyzed.
Conclusions. Different factors such as saliva characteristics, chewing or thermal and chemical
dietary changes may be responsible for the biodegradation of acrylic based resins. Release of
potential toxic compounds from the material and change on their physical and mechanical
properties are the major consequences of biodegradation. Increasing concern arises from
potential toxic effects of biodegradation products under clinical application thus justifying
an intensive research in this area.
Description
Keywords
Dental materials Acrylic based resins Polymethylmethacrylate Biodegradation Saliva Monomer release Cytotoxicity Water sorption