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Maternal acrylamide exposure during pregnancy and fetal growth: a systematic review and dose-response meta-analysis of epidemiological studies

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dc.contributor.authorHogervorst, Janneke
dc.contributor.authorVirgolino, Ana
dc.contributor.authorHalldorsson, Thorhallur I.
dc.contributor.authorVinceti, Marco
dc.contributor.authorÅkesson, Agneta
dc.contributor.authorLeander, Karin
dc.contributor.authorNawrot, Tim
dc.contributor.authorFilippini, Tommaso
dc.contributor.authorLaguzzi, Federica
dc.date.accessioned2022-09-09T14:17:04Z
dc.date.available2022-09-09T14:17:04Z
dc.date.issued2022
dc.description© 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)pt_PT
dc.description.abstractBackground: Acrylamide is a food contaminant linked to developmental toxicity in animals and possibly in humans. Objectives: We performed a systematic review and dose-response meta-analysis of epidemiological studies evaluating the relationship between maternal acrylamide exposure during pregnancy and the risk of being small for gestational age (SGA) and birth weight, birth head circumference and birth length. Methods: We performed the literature search in PubMed, Scopus, and Web of Science, until June 6th, 2022. Studies carried out in mother-newborn pairs, assessing maternal acrylamide exposure during pregnancy, either via dietary assessments or biomarkers i.e., hemoglobin adducts of acrylamide (AA-Hb) and glycidamide (GA-Hb), and evaluating birth outcomes were included. We employed a random-effects model to assess the pooled effect estimates and their 95% confidence intervals (CI) for the association between acrylamide exposure and birth outcomes. Risk of Bias for Nutrition Observational Studies tool was used for bias assessment. Results: Out of 169 records identified, five original studies were eligible, including 53,870 mother-newborn pairs in total. Means were 21.9 μg/day for estimated dietary acrylamide exposure (3 studies), and 18.4 and 14.9 pmol/g for AA-Hb and GA-Hb, respectively (2 studies). Higher risk of SGA and lower birth weight and head circumference were observed in the highest quartile of AA-Hb [odds ratio (OR): 1.20 (95% CI: 1.08; 1.33); mean difference (MD): -131 g (95% CI: -204; -58) and -0.31 cm (95% CI: -0.58; -0.04), respectively], and GA-Hb [OR: 1.36 (95% CI: 1.13; 1.64), MD: -161 g (95% CI: -271; -52); and MD: -0.38 cm (95% CI: -0.66; -0.10), respectively], whereas a lower birth length was observed only in the highest quartile of GA-Hb (MD: -0.85 cm (95% CI: -1.38; -0.33). Results from the dose-response meta-analysis between increasing maternal acrylamide exposure during pregnancy and birth weight showed no clear evidence of a deviation from linearity. Conclusions: Overall, our findings strengthen the evidence of an adverse effect of maternal acrylamide exposure during pregnancy on fetal growth. These results encourage to increase preventive actions towards lowering acrylamide exposure in the population.pt_PT
dc.description.sponsorshipThis work was supported by the European Union Horizon-2020 Research and Innovation Programme under grant agreement No. 733032 HBM4EU.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEnviron Res. 2022 Oct;213:113705pt_PT
dc.identifier.doi10.1016/j.envres.2022.113705pt_PT
dc.identifier.eissn1096-0953
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10451/54419
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/environmental-researchpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAcrylamidept_PT
dc.subjectBiomarkerspt_PT
dc.subjectDietary exposurept_PT
dc.subjectFetal growthpt_PT
dc.subjectGlycidamidept_PT
dc.subjectIn uteropt_PT
dc.titleMaternal acrylamide exposure during pregnancy and fetal growth: a systematic review and dose-response meta-analysis of epidemiological studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.startPage113705pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume213pt_PT
oaire.fundingStreamH2020
person.familyNameVirgolino
person.givenNameAna
person.identifier.ciencia-id1A10-C261-AC8E
person.identifier.orcid0000-0003-0428-6643
person.identifier.scopus-author-id56538593800
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa6f60fb1-2107-4c7a-b964-2482e43dcc54
relation.isAuthorOfPublication.latestForDiscoverya6f60fb1-2107-4c7a-b964-2482e43dcc54
relation.isProjectOfPublicationcb342690-27c4-49a3-a10b-bc958e33633d
relation.isProjectOfPublication.latestForDiscoverycb342690-27c4-49a3-a10b-bc958e33633d

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