Repository logo
 
Publication

Intestinal tissue-resident T cell activation depends on metabolite availability

2022Journal article Open access
Simple item page
dc.contributor.authorKonjar, Spela
dc.contributor.authorFerreira, Cristina
dc.contributor.authorCarvalho, Filipa
dc.contributor.authorFigueiredo-Campos, Patricia
dc.contributor.authorFanczal, Júlia
dc.contributor.authorRibeiro, Sofia
dc.contributor.authorMorais, Vanessa A.
dc.contributor.authorVeldhoen, Marc
dc.date.accessioned2025-06-03T13:38:22Z
dc.date.available2025-06-03T13:38:22Z
dc.date.issued2022
dc.descriptionCopyright © 2022 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND)pt_PT
dc.description.abstractThe metabolic capacity of many cells is tightly regulated and can adapt to changes in metabolic resources according to environmental changes. Tissue-resident memory (TRM) CD8+ T cells are one of the most abundant T cell populations and offer rapid protection against invading pathogens, especially at the epithelia. TRM cells metabolically adapt to their tissue niche, such as the intestinal epithelial barrier. In the small intestine, the types of TRM cells are intraepithelial lymphocytes (IELs), which contain high levels of cytotoxic molecules and express activation markers, suggesting a heightened state of activation. We hypothesize that the tissue environment may determine IEL activity. We show that IEL activation, in line with its semiactive status, is metabolically faster than circulating CD8+ T cells. IEL glycolysis and oxidative phosphorylation (OXPHOS) are interdependently regulated and are dependent on rapid access to metabolites from the environment. IELs are restrained by local availability of metabolites, but, especially, glucose levels determine their activity. Importantly, this enables functional control of intestinal TRM cells by metabolic means within the fragile environment of the intestinal epithelial barrier.pt_PT
dc.description.sponsorshipThe project that gave rise to these results has received funding from the following sources:” la Caixa” Foundation under Grant Agreement LCF/PR/HR19/52160005; European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreements 667824 and 679168; European Molecular Biology Organization under Grant Agreement IG/3309; Portuguese Foundation for Science and Technology under Grant Agreements IF/01693/2014, UID/BIM/50005/2019, and PTDC/MED-IMU/28003/2017; and European Regional Development Fund through the Lisbon Portugal Regional Operational Program under Grant Agreement PTDC/MED-IMU/28003/2017.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationProc Natl Acad Sci USA . 2022 Aug 23;119(34):e2202144119pt_PT
dc.identifier.doi10.1073/pnas.2202144119pt_PT
dc.identifier.eissn1091-6490
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/10400.5/101227
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Academy of Sciencespt_PT
dc.relationIG/3309pt_PT
dc.relationLeverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.
dc.relationQuality Control and Maintenance of Synaptic Mitochondria
dc.relationMaintaining Mitochondria Healthy: The Molecular Checkpoints involved in Mitochondrial Quality Control in Neurons
dc.relationRegulating the Epithelial Immune Network SUrveillance REsponse
dc.relation.publisherversionhttps://www.pnas.org/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectIELspt_PT
dc.subjectT cellspt_PT
dc.subjectGlucosept_PT
dc.subjectMetabolismpt_PT
dc.subjectTissue-resident memory T cellspt_PT
dc.titleIntestinal tissue-resident T cell activation depends on metabolite availabilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLeverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.
oaire.awardTitleQuality Control and Maintenance of Synaptic Mitochondria
oaire.awardTitleMaintaining Mitochondria Healthy: The Molecular Checkpoints involved in Mitochondrial Quality Control in Neurons
oaire.awardTitleRegulating the Epithelial Immune Network SUrveillance REsponse
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/667824/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/679168/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/IF%2F01693%2F2014%2FCP1236%2FCT0003/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Financiamento do Plano Estratégico de Unidades de I&D - 2019/UID%2FBIM%2F50005%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-IMU%2F28003%2F2017/PT
oaire.citation.issue34pt_PT
oaire.citation.titleProceedings of the National Academy of Sciencespt_PT
oaire.citation.volume119pt_PT
oaire.fundingStreamH2020
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFinanciamento do Plano Estratégico de Unidades de I&D - 2019
oaire.fundingStream9471 - RIDTI
person.familyNameKonjar
person.familyNameFerreira
person.familyNameCarvalho
person.familyNameFigueiredo-Campos
person.familyNameFanczal
person.familyNameRibeiro
person.familyNameMorais
person.familyNameVeldhoen
person.givenNameSpela
person.givenNameCristina
person.givenNameFilipa
person.givenNamePatricia
person.givenNameJúlia
person.givenNameSofia
person.givenNameVanessa
person.givenNameMarc
person.identifierhttps://scholar.google.pt/citations?hl=en&user=7vG1jLIAAAAJ
person.identifier.ciencia-idA219-1813-5FFE
person.identifier.ciencia-idEC16-8D36-C5F9
person.identifier.ciencia-idC411-273D-E50C
person.identifier.ciencia-id6413-A3A0-C7AD
person.identifier.orcid0000-0002-8969-0233
person.identifier.orcid0000-0001-6746-932X
person.identifier.orcid0000-0002-0074-0741
person.identifier.orcid0000-0002-9808-6230
person.identifier.orcid0000-0001-7356-3857
person.identifier.orcid0000-0002-0265-0416
person.identifier.orcid0000-0002-0830-0548
person.identifier.orcid0000-0002-1478-9562
person.identifier.ridF-3215-2011
person.identifier.scopus-author-id26424235400
person.identifier.scopus-author-id8323789000
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationbfa4fd3e-d4a9-40ed-acca-5b874fd13527
relation.isAuthorOfPublicationc69e126d-4827-447c-bd87-fef753aa96a4
relation.isAuthorOfPublication1c7a8748-8872-47dd-82e2-e63af9058c39
relation.isAuthorOfPublication0aa06c83-fd50-4c84-a33b-c930e6ac7871
relation.isAuthorOfPublication4e48b4c4-7ee1-4b7c-ba38-58006ae3e57f
relation.isAuthorOfPublication849ba962-dfec-45a6-91fb-09ef937af093
relation.isAuthorOfPublicationc56a6aed-0a74-403f-8e75-bfb503813545
relation.isAuthorOfPublicationb6ddef66-b6bb-4ce5-b68a-e4b211aa2411
relation.isAuthorOfPublication.latestForDiscoveryc69e126d-4827-447c-bd87-fef753aa96a4
relation.isProjectOfPublication7a4a0b51-ecdc-4c02-9d2b-0ac079311b63
relation.isProjectOfPublication5ff27adb-a6db-49da-a75e-e29d88086d68
relation.isProjectOfPublication58c5bd8b-2dc8-46ef-8974-e6242ba152de
relation.isProjectOfPublication79eb2b1b-7d61-428f-b371-08e871bfc6bf
relation.isProjectOfPublication7e630484-ad0c-4281-9ec3-c1c2a502187a
relation.isProjectOfPublication.latestForDiscovery7e630484-ad0c-4281-9ec3-c1c2a502187a

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Intestinal_tissue.pdf
Size:
1.92 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais