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TASTY trial: protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis

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dc.contributor.authorCharneca, Sofia
dc.contributor.authorHernando, Ana
dc.contributor.authorAlmada-Correia, Inês
dc.contributor.authorPolido Pereira, Joaquim
dc.contributor.authorVieira, Adriana
dc.contributor.authorSousa, Joana
dc.contributor.authorAlmeida, Ana S.
dc.contributor.authorMotta, Carla Motta
dc.contributor.authorBarreto, Gonçalo
dc.contributor.authorEklund, Kari K.
dc.contributor.authorAlnso‑Pérez, Ana
dc.contributor.authorGómez, Rodolfo
dc.contributor.authorCicc, Francesco
dc.contributor.authorMauro, Daniele
dc.contributor.authorPinho, Salomé S.
dc.contributor.authorFonseca, João Eurico
dc.contributor.authorCosta Reis, Patricia
dc.contributor.authorGuerreiro, Catarina Sousa
dc.date.accessioned2025-07-28T14:11:26Z
dc.date.available2025-07-28T14:11:26Z
dc.date.issued2025
dc.description© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractBackground: The gut microbiota has been implicated in the onset and progression of Rheumatoid Arthritis (RA). It has been proposed that gut dysbiosis impairs gut barrier function, leading to alterations in mucosal integrity and immunity. This disruption allows bacterial translocation, contributing to the perpetuation of the inflammatory process. Since diet is recognised as a key environmental factor influencing the gut microbiota, nutritional interventions targeting RA activity are currently being explored. This study aims to investigate whether a dietary intervention based on a typical Mediterranean Diet enriched with fermented foods (MedDiet +) can impact the gut microbiota, intestinal permeability, and RA-related outcomes. Methods: One hundred RA patients are being recruited at Unidade Local de Saúde (ULS) Santa Maria in Lisbon, Portugal, and randomly assigned to either the intervention (MedDiet +) or the control group. The 12-week nutritional intervention includes a personalised dietary plan following the MedDiet + pattern, along with educational resources, food basket deliveries, and clinical culinary workshops, all developed and monitored weekly by registered dietitians. The control group receives standardised general healthy diet recommendations at baseline. The intervention's effects will be assessed by evaluating disease activity, functional status, quality of life, intestinal permeability, endotoxemia, inflammatory biomarkers, intestinal and oral microbiota, serum proteomics, and serum glycome profile characterisation. Discussion: We anticipate obtaining integrative insights into the interplay between diet, the gut, and RA, while also exploring the underlying mechanisms driving these changes. This study, conducted by a multidisciplinary research team of registered dietitians, rheumatologists, biologists, and immunologists, aims to bridge the current gap between nutrition-related knowledge and RA. Trial registration: Registered in ClinicalTrials.gov (NCT06758817; date of registry: January 6th 2025).pt_PT
dc.description.sponsorshipOpen Access funding provided by University of Helsinki (including Helsinki University Central Hospital). This project has received funding from the European Union's Horizon Europe research and innovation programme under grant agreement No 101095084 (primary sponsor; contact information of the ENDOTARGET Project Coordinator: kari.eklund@hus.fi). This work was also supported by the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number 22.00462 and Fundação para a Ciência e a Tecnologia (FCT–Grant 2022.07462; principal investigator contact information: cfguerreiro@medicina.ulisboa.pt). SSP acknowledges funding by the European Union (GlycanTrigger, Grant Agreement Nº: 101093997). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. ASA is supported by a grant from Fundação para a Ciência e Tecnologia (2021.02791.CEECIND) and by iMM-CARE. iMM-CARE is funded by the European Union’s Horizon Europe research and innovation programme under grant agreement No. 101060102. iMM-CARE is co-funded by the Portuguese Government, the National Foundation for Science and Technology (FCT), the Francisco Manuel dos Santos Society Group (ARICA – Investimentos, Participações e Gestão and Jerónimo Martins), the Gulbenkian Institute for Molecular Medicine and CAML—Lisbon Academic Medical Centre.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutr J. 2025 Apr 7;24(1):52pt_PT
dc.identifier.doi10.1186/s12937-025-01089-6pt_PT
dc.identifier.eissn1475-2891
dc.identifier.urihttp://hdl.handle.net/10400.5/102474
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation101095084pt_PT
dc.relation101093997pt_PT
dc.relationMISSION – The power of Microbiota to modulate the Immune reSponSe In cOlorectal caNcer
dc.relation.publisherversionhttps://nutritionj.biomedcentral.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEndotoxemiapt_PT
dc.subjectIntestinal permeabilitypt_PT
dc.subjectMediterranean dietpt_PT
dc.subjectMicrobiotapt_PT
dc.subjectRheumatoid arthritispt_PT
dc.titleTASTY trial: protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMISSION – The power of Microbiota to modulate the Immune reSponSe In cOlorectal caNcer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.07462.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.02791.CEECIND%2FCP1673%2FCT0011/PT
oaire.citation.titleNutrition Journalpt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCEEC IND4ed
person.familyNameChinita Charneca
person.familyNameHernando
person.familyNameAlmada-Correia
person.familyNamePolido Pereira
person.familyNameSousa
person.familyNameSantos Almeida
person.familyNameFonseca
person.familyNameCosta Reis
person.familyNamesousa guerreiro
person.givenNameSofia Margarida
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person.givenNameInês
person.givenNameJoaquim
person.givenNameJoana
person.givenNameAna
person.givenNameJoão
person.givenNamePatricia
person.givenNamecatarina
person.identifier743899
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person.identifier.ciencia-idFC12-D310-411E
person.identifier.ciencia-id7D16-B608-1D52
person.identifier.ciencia-idC51C-82A3-2F4D
person.identifier.ciencia-id9812-232A-B282
person.identifier.ciencia-idFB1E-CB70-29A8
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.ciencia-id311F-89E5-532C
person.identifier.orcid0000-0002-0426-0462
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person.identifier.orcid0000-0002-7188-8516
person.identifier.orcid0000-0002-7875-0149
person.identifier.orcid0000-0001-8997-2639
person.identifier.orcid0000-0003-1432-3671
person.identifier.orcid0000-0002-7174-8302
person.identifier.orcid0000-0002-8730-6517
person.identifier.ridF-5317-2018
person.identifier.scopus-author-id7101983519
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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