Integrating sleep-related breathing disorders and epigenetics into the genetic landscape of sleep disturbances in psychotic disorders

Perdigoto, Susana; De Pedro, Miguel; Meira e Cruz, Miguel

http://hdl.handle.net/10400.5/102457

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Authors

Perdigoto, Susana

De Pedro, Miguel

Meira e Cruz, Miguel

Abstract(s)

Recent advances in psychiatric genetics have underscored the role of polygenic scores (PGSs) in shaping sleep phenotypes in individuals with psychotic disorders. The study by Cederlöf et al. (Reference Cederlöf, Holm, Kämpe, Ahola-Olli, Kantojärvi, Lähteenvuo and Paunio2025) makes an important contribution by leveraging genome-wide association data to disentangle the complex interplay between genetic liability for insomnia, sleep duration, chronotype, and schizophrenia. Their findings offer compelling insights into how distinct genetic risks manifest in both subjective experiences and cognitive performance. Yet, the genetic landscape of sleep in psychosis is even more nuanced than the current framework suggests. Several biologically and clinically relevant dimensions—namely sleep-related breathing disorders (SRBDs), the COMISA phenotype (comorbid insomnia and sleep apnea), and the dynamic influence of epigenetic regulation—warrant deeper integration into this conversation.

Description

© The Author(s), 2025. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:// creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.

Keywords

COMISA Comorbid insomnia and sleep apnea Epigenetics Genetics Insomnia Obstructive sleep apnea Psychiatric Psychosocial health Psychotic disorders Sleep apnea Sleep disturbances Sleep-disordered breathing