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Systematic Review of Platelet-Rich Plasma for Low Back Pain

2023-08-28Artigo científico Acesso aberto
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dc.contributor.authorSilva Machado, Edilson
dc.contributor.authorSoares, Fabiano Pasqualotto
dc.contributor.authorVianna de Abreu, Ernani
dc.contributor.authorde Souza, Taís Amara da Costa
dc.contributor.authorMeves, Robert
dc.contributor.authorGrohs, Hans
dc.contributor.authorAmbach, Mary A.
dc.contributor.authorNavani, Annu
dc.contributor.authorde Castro, Renato Bevillaqua
dc.contributor.authorDH, Pozza
dc.contributor.authorCaldas, José Manuel Peixoto
dc.date.accessioned2024-03-14T16:54:33Z
dc.date.available2024-03-14T16:54:33Z
dc.date.issued2023-08-28
dc.description.abstractBackground: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine. The present study aims to evaluate the efficacy of PRP injections in managing low back pain. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, a registered at PROSPERO Systematic Reviews Platform, under number CRD42021268491. The PubMed, Web of Science, and Scopus databases were searched to identify relevant articles, along with hand searching to identify gray literature articles, with no language restrictions. Randomized clinical trials (RCTs), nonrandomized trials (NRTs), and case series (CSs) with more than 10 patients were considered eligible. The quality assessment and the risk of bias of the randomized clinical trials were evaluated using the RoB II tool. An evaluation of the description of the preparation methods was performed using an adapted version of the MIBO checklist. Results: An electronic database search resulted in 2324 articles, and after the exclusion of noneligible articles, 13 RCTs and 27 NRTs or CSs were analyzed. Of the 13 RCTs, 11 found favorable results in comparison to the control group in pain and disability, one showed no superiority to the control group, and one was discontinued because of the lack of therapeutic effect at eight-week evaluation. Description of the PRP preparation techniques were found in almost all papers. The overall risk of bias was considered high in 2 papers and low in 11. An adapted MIBO checklist showed a 72.7% compliance rate in the selected areas. Conclusions: In this systematic review, we analyzed articles from English, Spanish and Russian language, from large databases and grey literature. PRP was in general an effective and safe treatment for degenerative LPB. Positive results were found in almost studies, a small number of adverse events were related, the risk of bias of the RCTs was low. Based on the evaluation of the included studies, we graded as level II the quality of the evidence supporting the use of PRP in LBP. Large-scale, multicenter RCTs are still needed to confirm these findings.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado, E.S.; Soares, F.P.; Vianna de Abreu, E.; de Souza, T.A.d.C.; Meves, R.; Grohs, H.; Ambach, M.A.; Navani, A.; de Castro, R.B.; Pozza, D.H.; et al. Systematic Review of Platelet-Rich Plasma for Low Back Pain. Biomedicines 2023, 11, 2404. https://doi.org/10.3390/biomedicines11092404pt_PT
dc.identifier.doi10.3390/biomedicines11092404pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/30403
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPlatelet-rich Plasma; Low Back Pain; Discogenic Pain; Facet Pain; Orthobiologics; Regenerative Medicine; Spinal Injection; Epidural Injection.pt_PT
dc.titleSystematic Review of Platelet-Rich Plasma for Low Back Painpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue9pt_PT
oaire.citation.startPage2404pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume11pt_PT
person.familyNameSilva Machado
person.familyNameSoares
person.familyNamePozza
person.givenNameEdilson
person.givenNameFabiano
person.givenNameDaniel
person.identifier2753313
person.identifier1126483
person.identifier.ciencia-id4516-6518-83F9
person.identifier.orcid0000-0002-0332-572X
person.identifier.orcid0000-0002-2815-4111
person.identifier.orcid0000-0002-2119-4479
person.identifier.scopus-author-id24073456900
person.identifier.scopus-author-id9238813700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication70272f86-ee50-4f5b-b5ba-fbb5a05e3103
relation.isAuthorOfPublicationb81c6981-6838-4b70-895b-e7bdf93b6af6
relation.isAuthorOfPublication018c561f-2ca9-404b-b99f-57bda29f94d3
relation.isAuthorOfPublication.latestForDiscoveryb81c6981-6838-4b70-895b-e7bdf93b6af6

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