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Authors
Abstract(s)
O estágio integrado no Mestrado de Análises Clínicas (MAC) decorreu no Laboratório de Análises Clínicas Dr. Joaquim Chaves (LACJC) no período de 03 de fevereiro a 05 de novembro de 2020, sob supervisão da Dra. Marina Pires, Farmacêutica Especialista em Análises Clínicas pela Ordem dos Farmacêuticos.
O estágio englobou as seguintes valências e respetivos tempos de duração: Microbiologia (225 horas), Hematologia (185 horas), Genética (55 horas), Bioquímica (200 horas) e Imunologia (85 horas).
Integrei em todas as valências nas rotinas diárias de trabalho, tomei conhecimento das metodologias utilizadas nos sistemas analíticos e técnicas manuais e acompanhei procedimentos de calibração; aprofundei conhecimentos relativos ao valor semiológico dos parâmetros determinados e quais os critérios de validação dos resultados através da avaliação presuntiva de que o erro associado aos resultados é inferior ao que foi definido como sendo o erro máximo admissível.
Resumo da monografia
Esta monografia pretende abordar o sistema endócrino, com ênfase no eixo hipotálamo-hipófise-suprarrenal. É efetuada uma descrição da anatomia e fisiologia de cada glândula, uma abordagem ao mecanismo de regulação, bem como as várias patologias associadas.
Assim, as alterações descritas podem implicar a produção excessiva ou secreção deficiente de mineralocorticoides, glicocorticoides ou androgénios no córtex da glândula suprarrenal, originando doenças como, por exemplo, a síndrome de Cushing, a doença de Addison, a síndrome de Conn, entre outras, ou podem, ainda, estar relacionadas com a produção excessiva de catecolaminas na medula da glândula suprarrenal, contribuindo para a existência de tumores como o feocromocitoma.
Por fim, será abordado de que forma o laboratório de Análises Clínicas contribui na avaliação e diagnóstico de algumas das patologias associadas.
The internship of the master’s in clinical analysis took place at Clinical Analysis Laboratory Dr. Joaquim Chaves from February 3rd to November 5th, 2020, under the supervision of Dr. Marina Pires, pharmaceutical specialist in clinical analysis. The internship was composed by the following topics and corresponding duration times: microbiology (225 hours), hematology (185 hours), genetics (55 hours), biochemistry (200 hours) and immunology (85 hours). During the internship I followed all the typical procedures during a working day, took note of all the methodologies used in the analytical systems and manual techniques and I watched on the calibration procedures. Moreover, I also deepen my knowledge on the semiological parameters and what were the criteria for validation of results via a preventive assessment that any error associated to the results must be lower than the maximum admissible error. Abstract - monography This monography will address the endocrine system, with special emphasis on the hypothalamus-pituitary-adrenal axis. A description of the anatomy and physiology of each gland, alongside with a description of the regulation mechanisms and associated pathologies is performed. Potential changes can lead to excessive production or insufficient secretion of mineralocorticoids, glucocorticoids and androgens in the suprarenal gland of the cortex, promoting diseases such as the Cushing’s syndrome, Addison’s disease, Conn’s syndrome, among others that are related to the excessive production of catecholamines in the medulla of the adrenal gland, promoting the formation of tumors such as pheochromocytoma. Finally, I’ll address how the laboratory of clinical analysis contributed to the evaluation and diagnosis of some associated pathologies.
The internship of the master’s in clinical analysis took place at Clinical Analysis Laboratory Dr. Joaquim Chaves from February 3rd to November 5th, 2020, under the supervision of Dr. Marina Pires, pharmaceutical specialist in clinical analysis. The internship was composed by the following topics and corresponding duration times: microbiology (225 hours), hematology (185 hours), genetics (55 hours), biochemistry (200 hours) and immunology (85 hours). During the internship I followed all the typical procedures during a working day, took note of all the methodologies used in the analytical systems and manual techniques and I watched on the calibration procedures. Moreover, I also deepen my knowledge on the semiological parameters and what were the criteria for validation of results via a preventive assessment that any error associated to the results must be lower than the maximum admissible error. Abstract - monography This monography will address the endocrine system, with special emphasis on the hypothalamus-pituitary-adrenal axis. A description of the anatomy and physiology of each gland, alongside with a description of the regulation mechanisms and associated pathologies is performed. Potential changes can lead to excessive production or insufficient secretion of mineralocorticoids, glucocorticoids and androgens in the suprarenal gland of the cortex, promoting diseases such as the Cushing’s syndrome, Addison’s disease, Conn’s syndrome, among others that are related to the excessive production of catecholamines in the medulla of the adrenal gland, promoting the formation of tumors such as pheochromocytoma. Finally, I’ll address how the laboratory of clinical analysis contributed to the evaluation and diagnosis of some associated pathologies.
Description
Tese de mestrado, Análises Clínicas, 2021, Universidade de Lisboa, Faculdade de Farmácia.
Keywords
Microbiologia Hematologia Genética Bioquímica Imunologia Insuficiência da glândula suprarrenal Síndrome de Cushing Doença de Addison Síndrome de Conn Hiperplasia suprarrenal congénita Teses de mestrado - 2021