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From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases

2022-03-15Artigo científico Acesso aberto
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dc.contributor.authorCaseiro, Catarina
dc.contributor.authorDias, Joana N. R.
dc.contributor.authorFontes, Carlos M.G.A.
dc.contributor.authorBule, Pedro
dc.date.accessioned2022-04-25T21:52:29Z
dc.date.available2022-04-25T21:52:29Z
dc.date.issued2022-03-15
dc.descriptionResearch Areas: Biochemistry & Molecular Biology ; Chemistrypt_PT
dc.description.abstract: β-glucans are a diverse group of polysaccharides composed of β-1,3 or β-(1,3-1,4) linked glucose monomers. They are mainly synthesized by fungi, plants, seaweed and bacteria, where they carry out structural, protective and energy storage roles. Because of their unique physicochemical properties, they have important applications in several industrial, biomedical and biotechnological processes. β-glucans are also major bioactive molecules with marked immunomodulatory and metabolic properties. As such, they have been the focus of many studies attesting to their ability to, among other roles, fight cancer, reduce the risk of cardiovascular diseases and control diabetes. The physicochemical and functional profiles of β-glucans are deeply influenced by their molecular structure. This structure governs β-glucan interaction with multiple β-glucan binding proteins, triggering myriad biological responses. It is then imperative to understand the structural properties of β-glucans to fully reveal their biological roles and potential applications. The deconstruction of β-glucans is a result of β-glucanase activity. In addition to being invaluable tools for the study of β-glucans, these enzymes have applications in numerous biotechnological and industrial processes, both alone and in conjunction with their natural substrates. Here, we review potential applications for β-glucans and β-glucanases, and explore how their functionalities are dictated by their structure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCaseiro C, Dias JNR, Andrade Fontes CMG, Bule P. 2022. From cancer therapy to winemaking : the molecular structure and applications of β-Glucans and β-1, 3-Glucanases. International Journal of Molecular Sciences, 23(6):3156. Doi 10.3390/ ijms23063156pt_PT
dc.identifier.doi10.3390/ ijms23063156pt_PT
dc.identifier.eissn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.5/24157
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationLA/P/0059/2020pt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relationALTERADO PARA: Glycoprobing: Exploring the CAZy database for novel catalysts with potential biotechnological and medical applications” Fungal nanomachines: understanding cellulosome assembly in ruminal fungi
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/6/3156pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectβ-glucanspt_PT
dc.subjectβ-glucanasespt_PT
dc.subjectMolecular structurept_PT
dc.subjectCancerpt_PT
dc.subjectDectin-1pt_PT
dc.subjectCR3pt_PT
dc.subjectVaccinespt_PT
dc.titleFrom cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00276/2020
oaire.awardNumberSFRH/BD/147152/2019
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardTitleALTERADO PARA: Glycoprobing: Exploring the CAZy database for novel catalysts with potential biotechnological and medical applications” Fungal nanomachines: understanding cellulosome assembly in ruminal fungi
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F147152%2F2019/PT
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23(6):3156pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
person.familyNameFino Caseiro
person.familyNameDias
person.familyNameFontes
person.familyNameBule
person.givenNameCatarina Sofia
person.givenNameJoana
person.givenNameCarlos
person.givenNamePedro
person.identifier1421801
person.identifier.ciencia-idB411-C6D9-B7D0
person.identifier.ciencia-id0813-845C-EFD5
person.identifier.ciencia-idC01A-FCB3-7F99
person.identifier.ciencia-id171E-F0CF-89F7
person.identifier.orcid0000-0003-1905-1871
person.identifier.orcid0000-0002-1219-9753
person.identifier.orcid0000-0003-2531-9926
person.identifier.scopus-author-id7005517465
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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