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From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
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Orientador(es)
Resumo(s)
: β-glucans are a diverse group of polysaccharides composed of β-1,3 or β-(1,3-1,4) linked
glucose monomers. They are mainly synthesized by fungi, plants, seaweed and bacteria, where they
carry out structural, protective and energy storage roles. Because of their unique physicochemical
properties, they have important applications in several industrial, biomedical and biotechnological
processes. β-glucans are also major bioactive molecules with marked immunomodulatory and
metabolic properties. As such, they have been the focus of many studies attesting to their ability
to, among other roles, fight cancer, reduce the risk of cardiovascular diseases and control diabetes.
The physicochemical and functional profiles of β-glucans are deeply influenced by their molecular
structure. This structure governs β-glucan interaction with multiple β-glucan binding proteins,
triggering myriad biological responses. It is then imperative to understand the structural properties
of β-glucans to fully reveal their biological roles and potential applications. The deconstruction of
β-glucans is a result of β-glucanase activity. In addition to being invaluable tools for the study of
β-glucans, these enzymes have applications in numerous biotechnological and industrial processes,
both alone and in conjunction with their natural substrates. Here, we review potential applications
for β-glucans and β-glucanases, and explore how their functionalities are dictated by their structure.
Descrição
Research Areas: Biochemistry & Molecular Biology ; Chemistry
Palavras-chave
β-glucans β-glucanases Molecular structure Cancer Dectin-1 CR3 Vaccines
Contexto Educativo
Citação
Caseiro C, Dias JNR, Andrade Fontes CMG, Bule P. 2022. From cancer therapy to winemaking : the molecular structure and applications of β-Glucans and β-1, 3-Glucanases. International Journal of Molecular Sciences, 23(6):3156. Doi 10.3390/ ijms23063156
Editora
MDPI