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Evaluation of the clinical sensitivities of three viral load assays with plasma samples from a pediatric population predominantly infected with human immunodeficiency virus type 1 subtype G and BG recombinant forms

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dc.contributor.authorAntunes, Rute
dc.contributor.authorFigueiredo, Sofia
dc.contributor.authorBártolo, Inês
dc.contributor.authorPinheiro, Manuel
dc.contributor.authorRosado, Lino
dc.contributor.authorSoares, Isabel
dc.contributor.authorLourenço, Helena
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2025-08-14T21:26:47Z
dc.date.available2025-08-14T21:26:47Z
dc.date.issued2003
dc.date.updated2023-02-03T14:50:30Z
dc.descriptionCopyright © 2003, American Society for Microbiology. All Rights Reserved.pt_PT
dc.description.abstractThe viral load assays AMPLICOR HIV-1 Monitor Test 1.5, Nuclisens HIV-1 QT, and Quantiplex HIV RNA 3.0 (bDNA) were evaluated for their abilities to quantify human immunodeficiency virus type 1 (HIV-1) RNA in 64 plasma samples from 21 children infected in Portugal. The children were infected with HIV-1 subtypes A1, B, F1, G, and BG recombinant virus. AMPLICOR v1.5 and Quantiplex v3.0 detected all samples, and there was a good correlation of results between the two kits. Thirty-eight specimens containing HIV-1 subtype B, G, or recombinant BG, could not be detected by Nuclisens HIV-1 QT. We also evaluated the new Retina HIV-1 assay on 21 samples that were HIV-1 positive; Retina HIV-1 failed to detect 5 of 11 subtype G specimens. AMPLICOR v1.5 and Quantiplex v3.0 assays may be used for HIV-1 RNA quantification in Portugal, whereas an improvement in sensitivity for subtype G and recombinant BG is required for Nuclisens HIV-1 QT and Retina HIV-1.pt_PT
dc.description.sponsorshipCritical review of the manuscript by Anne-Mieke Vandamme is gratefully acknowledged. This work was partially supported by grants CRIA-CR3751 and CR3753 from Comissão Nacional de Luta Contra a SIDA (CNLS), Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntunes R, Figueiredo S, Bártolo I, Pinheiro M, Rosado L, Soares I, et al. Evaluation of the Clinical Sensitivities of Three Viral Load Assays with Plasma Samples from a Pediatric Population Predominantly Infected with Human Immunodeficiency Virus Type 1 Subtype G and BG Recombinant Forms. J Clin Microbiol 2003;41:3361–7. https://doi.org/10.1128/JCM.41.7.3361-3367.2003.pt_PT
dc.identifier.doi10.1128/JCM.41.7.3361-3367.2003pt_PT
dc.identifier.eid2-s2.0-0037829662
dc.identifier.slugcv-prod-1108465
dc.identifier.urihttp://hdl.handle.net/10400.5/102925
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/jcm.41.7.3361-3367.2003pt_PT
dc.titleEvaluation of the clinical sensitivities of three viral load assays with plasma samples from a pediatric population predominantly infected with human immunodeficiency virus type 1 subtype G and BG recombinant formspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3367pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage3361pt_PT
oaire.citation.titleJournal of Clinical Microbiologypt_PT
oaire.citation.volume41pt_PT
person.familyNameBártolo
person.familyNameTaveira
person.givenNameInês
person.givenNameNuno
person.identifier318426
person.identifier476379
person.identifier.ciencia-id661E-F5CB-F85A
person.identifier.ciencia-id7111-3383-A926
person.identifier.orcid0000-0002-2022-8921
person.identifier.orcid0000-0003-0176-5585
person.identifier.ridA-7477-2014
person.identifier.ridA-6252-2014
person.identifier.scopus-author-id8418824400
person.identifier.scopus-author-id6602731390
rcaap.cv.cienciaid661E-F5CB-F85A | Inês Bártolo
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication17555d0a-4e10-49ce-b415-00fe51b57cfd
relation.isAuthorOfPublicationb57e2ea6-7336-4f8f-96a9-9ff4677829ee
relation.isAuthorOfPublication.latestForDiscovery17555d0a-4e10-49ce-b415-00fe51b57cfd

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