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Ecotoxicity of the lipid-lowering drug bezafibrate on the bioenergetics and lipid metabolism of the diatom Phaeodactylum tricornutum

2019Journal article Restricted access
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dc.contributor.authorDuarte, Bernardo
dc.contributor.authorPrata, Diogo
dc.contributor.authorMatos, Ana Rita
dc.contributor.authorCabrita, Maria Teresa
dc.contributor.authorCaçador, Isabel
dc.contributor.authorMarques, J. C.
dc.contributor.authorCabral, Henrique
dc.contributor.authorReis Santos, Patrick
dc.contributor.authorFonseca, Vanessa
dc.date.accessioned2019-06-25T09:46:35Z
dc.date.available2019-06-25T09:46:35Z
dc.date.issued2019
dc.description.abstractPharmaceutical residues impose a new and emerging threat to the marine environment and its biota. In most countries, ecotoxicity tests are not required for all pharmaceutical residues classes and, even when mandatory, these tests are not performed using marine primary producers such as diatoms. These microalgae are among the most abundant class of primary producers in the marine realm and key players in the marine trophic web. Blood-lipid-lowering agents such as bezafibrate and its derivatives are among the most prescribed drugs and most frequently found human pharmaceuticals in aquatic environments. The present study aims to investigate the bezafibrate ecotoxicity and its effects on primary productivity and lipid metabolism, at environmentally relevant concentrations, using the model diatom Phaeodactylum tricornutum. Under controlled conditions, diatom cultures were exposed to bezafibrate at 0, 3, 6, 30 and 60 μg L-1, representing concentrations that can be found in the vicinity of discharges of wastewater treatment plants. High bezafibrate concentrations increased cell density and are suggested to promote a shift from autotrophic to mixotrophic metabolism, with diatoms using light energy generated redox potential to breakdown bezafibrate as carbon source. This was supported by an evident increase in cell density coupled with an impairment of the thylakoid electron transport and consequent photosynthetic activity reduction. In agreement, the concentrations of plastidial marker fatty acids showed negative correlations and Canonical Analysis of Principal coordinates of the relative abundances of fatty acid and photochemical data allowed the separation of controls and cells exposed to bezafibrate with high classification efficiency, namely for photochemical traits, suggesting their validity as suitable biomarkers of bezafibrate exposure. Further evaluations of the occurrence of a metabolic shift in diatoms due to exposure to bezafibrate is paramount, as ultimately it may reduce O2 generation and CO2 fixation in aquatic ecosystems with ensuing consequences for neighboring heterotrophic organisms.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.scitotenv.2018.09.354pt_PT
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10451/38800
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectFibratespt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectMarine primary producerpt_PT
dc.subjectPhotochemistrypt_PT
dc.subjectFatty acidspt_PT
dc.titleEcotoxicity of the lipid-lowering drug bezafibrate on the bioenergetics and lipid metabolism of the diatom Phaeodactylum tricornutumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2094pt_PT
oaire.citation.startPage2085pt_PT
oaire.citation.titleScience of the Total Environmentpt_PT
oaire.citation.volume650pt_PT
person.familyNameDuarte
person.familyNameCaçador
person.familyNameMARQUES
person.familyNameCabral
person.familyNameReis-Santos
person.familyNameFonseca
person.givenNameBernardo
person.givenNameIsabel
person.givenNameJOÃO CARLOS
person.givenNameHenrique
person.givenNamePatrick
person.givenNameVanessa
person.identifier89449
person.identifier134821
person.identifier138360
person.identifierhttps://scholar.google.com/citations?user=bTjfoO8AAAAJ&hl=en
person.identifier.ciencia-id731E-093F-D4C8
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person.identifier.ciencia-id1E11-AE01-98EC
person.identifier.orcid0000-0003-1914-7435
person.identifier.orcid0000-0002-4475-6091
person.identifier.orcid0000-0001-8865-8189
person.identifier.orcid0000-0002-7646-6208
person.identifier.orcid0000-0001-9843-9465
person.identifier.orcid0000-0002-6374-1194
person.identifier.ridH-2001-2011
person.identifier.ridC-2618-2012
person.identifier.ridL-9478-2014
person.identifier.ridD-5201-2011
person.identifier.scopus-author-id20734149900
person.identifier.scopus-author-id6602533871
person.identifier.scopus-author-id7203032961
person.identifier.scopus-author-id7006073782
person.identifier.scopus-author-id15835590000
person.identifier.scopus-author-id14021110600
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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