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Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies

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dc.contributor.authorFilippini, Tommaso
dc.contributor.authorHalldorsson, Thorhallur I.
dc.contributor.authorCapitão, Carolina
dc.contributor.authorMartins, Raquel
dc.contributor.authorGiannakou, Konstantinos
dc.contributor.authorHogervorst, Janneke
dc.contributor.authorVinceti, Marco
dc.contributor.authorÅkesson, Agneta
dc.contributor.authorLeander, Karin
dc.contributor.authorKatsonouri, Andromachi
dc.contributor.authorSantos, Osvaldo
dc.contributor.authorVirgolino, Ana
dc.contributor.authorLaguzzi, Federica
dc.date.accessioned2022-05-03T14:00:55Z
dc.date.available2022-05-03T14:00:55Z
dc.date.issued2022
dc.descriptionCopyright © 2022 Filippini, Halldorsson, Capitão, Martins, Giannakou, Hogervorst, Vinceti, Åkesson, Leander, Katsonouri, Santos, Virgolino and Laguzzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractDiet is a main source of acrylamide exposure to humans. Existing observational data on the relationship between dietary exposure to acrylamide and risk of cancer are inconsistent. We performed a systematic review and dose-response meta-analysis of epidemiological studies evaluating the association between dietary acrylamide exposure and several site-specific cancer. A systematic literature search was conducted in PubMed, Scopus, and Web of Science databases until March 7, 2022. Studies were eligible if they were carried out in non-occupationally exposed adults, assessed dietary acrylamide exposure (µg/day) and reported risk estimates of cancer incidence (all but gynecological cancers). Using a random-effects model, we performed a metaanalysis of site-specific cancer risk comparing the highest vs. lowest category of dietary acrylamide exposure. We also carried out a one-stage dose-response metaanalysis assessing the shape of the association. Out of 1,994 papers screened, 31 were eligible (total of 16 studies), which included 1,151,189 participants in total, out of whom 48,175 developed cancer during the median follow-up period of 14.9 years (range 7.3–33.9). The mean estimated dose of dietary acrylamide across studies was 23 µg/day. Pooled analysis showed no association between the highest vs. lowest dietary acrylamide exposure and each site-specific cancer investigated, with no evidence of thresholds in the dose-response meta-analysis. There were also no associations between dietary acrylamide exposure and the risk of cancers when stratifying by smoking status, except for increased risk of lung cancer in smokers. In conclusion, high dietary acrylamide exposure was not associated with an increased risk of site-specific non-gynecological cancer.pt_PT
dc.description.sponsorshipThis work was supported by the European Union Horizon-2020 Research and Innovation Programme under grant agreement No. 733032 HBM4EU.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront. Nutr., 25 April 2022, 9:875607pt_PT
dc.identifier.doi10.3389/fnut.2022.875607pt_PT
dc.identifier.eissn2296-861X
dc.identifier.urihttp://hdl.handle.net/10451/52652
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.frontiersin.org/journals/nutrition#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAcrylamidept_PT
dc.subjectDietary exposurept_PT
dc.subjectNeoplasmspt_PT
dc.subjectCarcinomapt_PT
dc.subjectSystematic reviewpt_PT
dc.subjectMeta-analysispt_PT
dc.subjectEpidemiological studiespt_PT
dc.titleDietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.titleFrontiers in Nutritionpt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamH2020
person.familyNameda Silva Gaspar de Areia Capitão
person.familyNameMartins
person.familyNameSantos
person.familyNameVirgolino
person.givenNameCarolina
person.givenNameRaquel
person.givenNameOsvaldo
person.givenNameAna
person.identifier.ciencia-id741A-8A14-36F5
person.identifier.ciencia-id191B-38D7-A7BF
person.identifier.ciencia-id1A10-C261-AC8E
person.identifier.orcid0000-0002-4614-0549
person.identifier.orcid0000-0002-6192-2266
person.identifier.orcid0000-0002-0836-4314
person.identifier.orcid0000-0003-0428-6643
person.identifier.scopus-author-id56538593800
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication4021471d-4b65-42f5-847e-58c309143148
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