A carregar...
Publicação
T follicular regulatory (Tfr) cells: dissecting the complexity of Tfr‐cell compartments
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 798.1 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Germinal centers (GC) have been known as key anatomic structures in humoral immunity, where isotype switching and affinity maturation occur. As a consequence, elucidation of GC regulation has potential implications for the understanding of autoantibody-mediated diseases. It is now accepted that different regulatory mechanisms coexist, including the action of a specialized population of Foxp3+ regulatory T cells with unique access to the B-cell follicle: the T follicular regulatory (Tfr) cells. Tfr cells develop through a multistep process requiring migration through different compartments of lymphoid tissues. This review discusses the ontogeny and physiology of Tfr cells, their distribution within distinct anatomic compartments, and their function. A greater understanding of Tfr biology and GC regulation is likely to lead to better stratification of patients with autoantibody-mediated diseases, and to the identification of novel therapeutic targets.
Descrição
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Palavras-chave
Foxp3 T follicular helper cells T follicular regulatory cells T regulatory cells Humoral responses Interleukin-2
Contexto Educativo
Citação
Immunol Rev. 2019 Mar;288(1):112-127
Editora
John Wiley & Sons, Inc.