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Authors
Abstract(s)
O vinho tinto é das bebidas alcoólicas mais antigas e consumidas no mundo. Os efeitos benéficos decorrentes do consumo moderado e regular do vinho tinto encontram-se associados ao elevado teor de polifenóis com atividade antioxidante. O resveratrol é uma fitoalexina polifenólica encontrada em diversos alimentos, e em particular no vinho tinto, sendo aqui sintetizada na casca da uva. O interesse do resveratrol tem vindo a aumentar devido à sua bioatividade traduzida nas atividades antioxidante, anti-inflamatória e anticancerígena. Desta forma, apresenta-se um estado da arte sobre os efeitos intracelulares e os efeitos a nível das membranas celulares do resveratrol, uma vez que o seu conhecimento é essencial para a compreensão das atividades farmacológicas e terapêuticas deste composto bioativo. No entanto, a aplicabilidade do resveratrol continua a ser um grande desafio para a indústria farmacêutica, nomeadamente devido à baixa estabilidade (face à oxidação) e baixa solubilidade em meio aquoso, comprometendo a sua biodisponibilidade.
Wine is probably the oldest and most consumed alcoholic beverage in the world. The beneficial effects of moderate and regular consumption of red wine are associated with high levels of polyphenols with antioxidant activity. Resveratrol is a polyphenolic phytoalexin found in a variety of foods, particularly in red wine, being here synthesized in grape skins. The interest in resveratrol has increased due to its bioactivity that include antioxidant, anti-inflammatory and anticancer activity. In this way, it presents a state of art about the intracellular effects and the effects at the cell membrane level because their knowledge is essential for understanding the pharmacological and therapeutic activities of this bioactive compound. However, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility in the aqueous medium, compromising their bioavailability.
Wine is probably the oldest and most consumed alcoholic beverage in the world. The beneficial effects of moderate and regular consumption of red wine are associated with high levels of polyphenols with antioxidant activity. Resveratrol is a polyphenolic phytoalexin found in a variety of foods, particularly in red wine, being here synthesized in grape skins. The interest in resveratrol has increased due to its bioactivity that include antioxidant, anti-inflammatory and anticancer activity. In this way, it presents a state of art about the intracellular effects and the effects at the cell membrane level because their knowledge is essential for understanding the pharmacological and therapeutic activities of this bioactive compound. However, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility in the aqueous medium, compromising their bioavailability.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019
Keywords
Vinho tinto, Polifenóis, Resveratrol, Atividade antioxidante, Atividade anti-inflamatória, Atividade anticancerígena Mestrado Integrado - 2019