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Antioxidant-Loaded Mucoadhesive Nanoparticles for Eye Drug Delivery: A New Strategy to Reduce Oxidative Stress

2021-02-19Journal article Open access
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dc.contributor.authorCordeiro, Sandra
dc.contributor.authorSilva, Beatriz
dc.contributor.authorMartins, Ana
dc.contributor.authorRibeiro, Helena
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorMarto, Joana
dc.date.accessioned2024-01-23T16:46:02Z
dc.date.available2024-01-23T16:46:02Z
dc.date.issued2021-02-19
dc.date.updated2023-02-27T15:59:35Z
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThere are several approaches to treat ocular diseases, which can be invasive or non-invasive. Within the non-invasive, new pharmaceutical strategies based on nanotechnology and mucoadhesive polymers are emerging methodologies, which aim to reach an efficient treatment of eye diseases. The aim of this work was the development of novel chitosan/hyaluronic acid nanoparticle systems with mucoadhesive properties, intended to encapsulate antioxidant molecules (e.g., crocin) aiming to reduce eye oxidative stress and, consequently, ocular disease. An ultraviolet (UV) absorber molecule, actinoquinol, was also added to the nanoparticles, to further decrease oxidative stress. The developed nanoparticles were characterized and the results showed a mean particle size lower than 400 nm, polydispersity index of 0.220 ± 0.034, positive zeta potential, and high yield. The nanoparticles were also characterized in terms of pH, osmolality, and viscosity. Mucoadhesion studies involving the determination of zeta potential, viscosity, and tackiness, showed a strong interaction between the nanoparticles and mucin. In vitro release studies using synthetic membranes in Franz diffusion cells were conducted to unravel the drug release kinetic profile. Ex vitro studies using pig eye scleras in Franz diffusion cells were performed to evaluate the permeation of the nanoparticles. Furthermore, in vitro assays using the ARPE-19 (adult retinal pigment epithelium) cell line showed that the nanoparticles can efficiently decrease oxidative stress and showed low cytotoxicity. Thus, the developed chitosan/hyaluronic acid nanoparticles are a promising system for the delivery of antioxidants to the eye, by increasing their residence time and controlling their delivery.pt_PT
dc.description.sponsorshipThis research was funded by the Fundação para a Ciência e Tecnologia, Portugal (UIDB/04138/2020 and UIDP/04138/2020 to iMed.ULisboa, CEECINST/00145/2018 to J.Marto and Principal Researcher grant CEECIND/03143/2017 (L.Gonçalves); FCT fellowship SFRH/BD/130476/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCordeiro S, Silva B, Martins AM, Ribeiro HM, Gonçalves L, Marto J. Antioxidant-loaded mucoadhesive nanoparticles for eye drug delivery: a new strategy to reduce oxidative stress. Processes [Internet]. 19 de fevereiro de 2021;9(2):379. Disponível em: https://www.mdpi.com/2227-9717/9/2/379pt_PT
dc.identifier.doi10.3390/pr9020379pt_PT
dc.identifier.slugcv-prod-2420941
dc.identifier.urihttp://hdl.handle.net/10451/62048
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relationNot Available
dc.relationNot Available
dc.relationNot Available
dc.relationNot Available
dc.relationRetinal erythropoietin distribution and neuroprotective effect in a nanoparticulate drug delivery system after subconjunctival and topical adminstration in an animal glaucoma model
dc.relation.publisherversionhttps://www.mdpi.com/2227-9717/9/2/379pt_PT
dc.subjectnanoparticlespt_PT
dc.subjectchitosanpt_PT
dc.subjecthyaluronic acidpt_PT
dc.subjectantioxidantpt_PT
dc.subjectmucoadhesivept_PT
dc.subjecteye drug deliverypt_PT
dc.titleAntioxidant-Loaded Mucoadhesive Nanoparticles for Eye Drug Delivery: A New Strategy to Reduce Oxidative Stresspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleRetinal erythropoietin distribution and neuroprotective effect in a nanoparticulate drug delivery system after subconjunctival and topical adminstration in an animal glaucoma model
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0003/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03143%2F2017%2FCP1476%2FCT0005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130476%2F2017/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage379pt_PT
oaire.citation.titleProcessespt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC IND 2017
person.familyNameMartins
person.familyNameRibeiro
person.familyNameDiogo Gonçalves
person.familyNameMarques Marto
person.givenNameAna
person.givenNameHelena
person.givenNameLídia Maria
person.givenNameJoana
person.identifier1570599
person.identifier.ciencia-id161F-B79B-D660
person.identifier.ciencia-id7211-22BA-86AD
person.identifier.ciencia-id891B-12E1-C2BF
person.identifier.orcid0000-0003-4822-3249
person.identifier.orcid0000-0002-2429-7991
person.identifier.orcid0000-0002-6799-2740
person.identifier.orcid0000-0001-5523-5622
person.identifier.ridE-2944-2015
person.identifier.scopus-author-id35896704400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid7211-22BA-86AD | Lídia Maria Diogo Gonçalves
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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