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Comfortably numb: ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutum

2020Journal article Restricted access
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dc.contributor.authorSilva, Marisa
dc.contributor.authorFeijão, Eduardo
dc.contributor.authorda Cruz de Carvalho, Ricardo
dc.contributor.authorDuarte, Irina A.
dc.contributor.authorMatos, Ana Rita
dc.contributor.authorCabrita, Maria Teresa
dc.contributor.authorBarreiro, Aldo
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorNovais, Sara C.
dc.contributor.authorMarques, João Carlos
dc.contributor.authorCaçador, Isabel
dc.contributor.authorReis-Santos, Patrick
dc.contributor.authorFonseca, Vanessa F.
dc.contributor.authorDuarte, Bernardo
dc.date.accessioned2021-05-11T14:32:15Z
dc.date.available2021-05-11T14:32:15Z
dc.date.issued2020
dc.description.abstractEmerging pollutants such as pharmaceuticals are continuously released to aquatic environments posing a rising threat to marine ecosystems. Yet, monitoring routines and ecotoxicity data on biota worldwide for these substances are lacking. Non-steroidal anti-inflammatory drugs are among the most prescribed and found pharmaceuticals in aquatic environments. The toxicity effects of environmentally relevant concentrations of ibuprofen on primary productivity, oxidative stress and lipid metabolism of the diatom Phaeodactylum tricornutum were assessed. Diatom cultures were exposed to 0, 0.8, 3, 40, 100 and 300 μg L-1 ibuprofen concentrations, usually found in the vicinity of wastewater treatment plants and coastal environments. Higher concentrations (100 and 300 μg L-1) had a negative impact in P. triconutum growth, inhibiting the chloroplastic energy transduction in the electron transport chain resulting in lower energy reaching the PS I (r2 = -0.55, p < 0.05). In contrast, the mitochondrial electron transport and available energy increased (r2 = 0.68 and r2 = 0.85, p < 0.05 respectively), mostly due to enhancements in lipid and protein contents as opposed to reduction of carbohydrates. A general up-regulation of the antioxidant enzymes could contributed to alleviate oxidative stress resulting in the decrease of lipid peroxidation products (r2 = 0.77, p < 0.05). Canonical analysis of principal components was performed and successfully discriminated exposure groups, with optical data excelling in classifying samples to different ibuprofen concentrations, being potentially used as environmental indicators. Finally, the identified mild to severe effects of ibuprofen on diatoms are likely to be exacerbated by the sustained use of this drug worldwide, underpinning the urgency of evaluating the impacts of this pharmaceutical on coastal and marine trophic webs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, M., Feijão, E., Carvalho, R. da C. de, Duarte, I. A., Matos, A. R., Cabrita, M. T., Duarte, B., et al. (2020). Comfortably numb: ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on phaeodactylum tricornutum. Marine Environmental Research, 161, 105109. https://doi.org/10.1016/j.marenvres.2020.105109pt_PT
dc.identifier.doi10.1016/j.marenvres.2020.105109pt_PT
dc.identifier.issn0141-1136
dc.identifier.urihttp://hdl.handle.net/10451/47759
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPTDC/CTAAMB/ 30056/2017pt_PT
dc.relationProTEoME - PROteomic Tools to assess Endocrine disruptiOn MEchanisms
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141113620305225?via%3Dihubpt_PT
dc.subjectAnti-Inflammatory Agents, Non-Steroidalpt_PT
dc.subjectEcosystempt_PT
dc.subjectIbuprofenpt_PT
dc.subjectDiatomspt_PT
dc.subjectWater Pollutants, Chemicalpt_PT
dc.titleComfortably numb: ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleProTEoME - PROteomic Tools to assess Endocrine disruptiOn MEchanisms
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FAAG-MAA%2F1302%2F2014/PT
oaire.citation.startPage105109pt_PT
oaire.citation.titleMarine Environmental Researchpt_PT
oaire.citation.volume161pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameCabrita
person.givenNameMaria Teresa
person.identifier349469
person.identifier.ciencia-id3E17-0125-F909
person.identifier.orcid0000-0002-4323-4945
person.identifier.ridB-5746-2014
person.identifier.scopus-author-id6602224932
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverycac05d5d-1ba9-4d1a-a052-d8bde9ecfadc
relation.isProjectOfPublicatione56b7081-6fdb-4690-88dd-778b891465c1
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