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From thymus to periphery : molecular basis of effector γδ‐T cell differentiation

2020Artigo científico Acesso aberto
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dc.contributor.authorFiala, Gina
dc.contributor.authorGomes, Anita Q.
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2021-04-08T12:52:30Z
dc.date.available2021-04-08T12:52:30Z
dc.date.issued2020
dc.description© 2020 The Authors. Immunological Reviews published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractThe contributions of γδ T cells to immune (patho)physiology in many pre-clinical mouse models have been associated with their rapid and abundant provision of two critical cytokines, interferon-γ (IFN-γ) and interleukin-17A (IL-17). These are typically produced by distinct effector γδ T cell subsets that can be segregated on the basis of surface expression levels of receptors such as CD27, CD44 or CD45RB, among others. Unlike conventional T cells that egress the thymus as naïve lymphocytes awaiting further differentiation upon activation, a large fraction of murine γδ T cells commits to either IFN-γ or IL-17 expression during thymic development. However, extrathymic signals can both regulate pre-programmed γδ T cells; and induce peripheral differentiation of naïve γδ T cells into effectors. Here we review the key cellular events of "developmental pre-programming" in the mouse thymus; and the molecular basis for effector function maintenance vs plasticity in the periphery. We highlight some of our contributions towards elucidating the role of T cell receptor, co-receptors (like CD27 and CD28) and cytokine signals (such as IL-1β and IL-23) in these processes, and the various levels of gene regulation involved, from the chromatin landscape to microRNA-based post-transcriptional control of γδ T cell functional plasticity.pt_PT
dc.description.sponsorshipThis work was funded by the European Research Council (CoG_646701 to BS‐S.). GJF is supported by a European Commission Marie Sklodowska‐Curie Individual Fellowship (ref. 752932).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationImmunol Rev. 2020 Nov;298(1):47-60pt_PT
dc.identifier.doi10.1111/imr.12918pt_PT
dc.identifier.eissn1600-065X
dc.identifier.issn0105-2896
dc.identifier.urihttp://hdl.handle.net/10451/47288
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Inc.pt_PT
dc.relationCoG_646701pt_PT
dc.relationTracking γδ T cell development and TCRγδ proximal signalling
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/1600065xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEffector T cell differentiationpt_PT
dc.subjectGamma-delta T cellspt_PT
dc.subjectIL-17pt_PT
dc.subjectThymic T cell developmentpt_PT
dc.titleFrom thymus to periphery : molecular basis of effector γδ‐T cell differentiationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumber752932
oaire.awardTitleTracking γδ T cell development and TCRγδ proximal signalling
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/752932/EU
oaire.citation.endPage60pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage47pt_PT
oaire.citation.titleImmunological Reviewspt_PT
oaire.citation.volume298pt_PT
oaire.fundingStreamH2020
person.familyNameFiala
person.familyNameGomes
person.familyNameSilva-Santos
person.givenNameGina
person.givenNameAnita
person.givenNameBruno
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.ciencia-idD51E-6517-BE6A
person.identifier.orcid0000-0002-8226-5584
person.identifier.orcid0000-0002-3348-0448
person.identifier.orcid0000-0003-4141-9302
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id7202386033
person.identifier.scopus-author-id6505885924
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd39d57a2-c9ee-411f-89b5-0b5690a72f5f
relation.isAuthorOfPublication329776ed-aea9-4b80-810c-50e80fc675f9
relation.isAuthorOfPublicationf313ff02-41ee-4014-88a1-bd641b6219bf
relation.isAuthorOfPublication.latestForDiscovery329776ed-aea9-4b80-810c-50e80fc675f9
relation.isProjectOfPublicationf23d0a7a-fbf1-4c38-9cff-71a606714062
relation.isProjectOfPublication.latestForDiscoveryf23d0a7a-fbf1-4c38-9cff-71a606714062

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