Publicação
Intermittent low-level lead exposure causes anxiety and cardiorespiratory impairment
| dc.contributor.author | Shvachiy, Liana | |
| dc.contributor.author | Geraldes, Vera | |
| dc.contributor.author | Amaro-Leal, Ângela | |
| dc.contributor.author | Rocha, Isabel | |
| dc.date.accessioned | 2019-11-05T15:12:50Z | |
| dc.date.available | 2019-11-05T15:12:50Z | |
| dc.date.issued | 2017 | |
| dc.description | Copyright © 2019 Ovid Technologies, Inc., and its partners and affiliates. All Rights Reserved. | pt_PT |
| dc.description.abstract | Aim: To characterize behavioural and cardiorespiratory changes in a new, intermittent low-level lead exposure animal model. Introduction: Lead (Pb) is a cumulative toxic metal affecting all body systems that are particularly vulnerable during developmental phase. Permanent lead exposure has been defined as a cause of behavioural changes, cognitive impairment, sympathoexcitation, tachycardia, hypertension and autonomic dysfunction. However, no studies have been performed to describe a new, intermittent low-level lead exposure profile, that has been increased in the past years. Methods: Foetuses were intermittently (PbI) exposed to water containing lead acetate (0.2%, w/v) throughout life until adulthood (28 weeks of age). A control group (without exposure, CTL), matching in age and sex was used. At 26 weeks, behavioural tests were performed for anxiety (Elevated Plus Maze Test) and locomotor activity (Open Field Test) assessment. Blood pressure (BP), electrocardiogram (ECG), heart rate (HR) and respiratory frequency (RF) rates were recorded at 28 weeks of age. Baroreflex gain (BRG) and chemoreflex sensitivity (ChS) were calculated. Student’s T-test was used (significance p < 0.05) for statistical analysis. Results: An intermittent lead exposure causes hypertension (increased diastolic and mean BP), increased RF, decreased baroreflex function and increased ChS, without significant changes in HR, when compared to CTL group. Regarding behavioral changes, the intermittent lead exposure model showed an anxiety-like behaviour without changes in locomotor activity. Conclusion: Intermittent low-level lead exposure induces changes on the cardiorespiratory profile characterized by hypertension, carotid chemosensitivity and baroreflex impairment. According to behavioural tests results, this study also shows that the exposure to lead during developmental phases causes anxiety in adult animals without locomotor activity impairment. In summary, this study brings new insights on the environmental factors that influence nervous and cardiovascular systems during development, which can help creating public policy strategies to prevent and control the adverse effects of Pb toxicity. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Porto Biomedical Journal. 2(5):229–230, Sep-Oct 2017 | pt_PT |
| dc.identifier.doi | 10.1016/j.pbj.2017.07.125 | |
| dc.identifier.issn | 2444-8664 | |
| dc.identifier.uri | http://hdl.handle.net/10451/40078 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Wolters Kluwer Health | pt_PT |
| dc.relation.publisherversion | https://journals.lww.com/pbj/pages/default.aspx | pt_PT |
| dc.title | Intermittent low-level lead exposure causes anxiety and cardiorespiratory impairment | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 230 | pt_PT |
| oaire.citation.issue | 5 | pt_PT |
| oaire.citation.startPage | 229 | pt_PT |
| oaire.citation.title | Porto Biomedical Journal | pt_PT |
| oaire.citation.volume | 2 | pt_PT |
| person.familyName | Shvachiy | |
| person.familyName | Geraldes | |
| person.familyName | Amaro Leal | |
| person.familyName | rocha | |
| person.givenName | Liana | |
| person.givenName | Vera | |
| person.givenName | Ângela Raquel | |
| person.givenName | isabel | |
| person.identifier.ciencia-id | CE1E-41FB-0835 | |
| person.identifier.ciencia-id | D51D-E96C-1633 | |
| person.identifier.ciencia-id | 2012-159D-850B | |
| person.identifier.orcid | 0000-0002-4576-0017 | |
| person.identifier.orcid | 0000-0003-1275-3459 | |
| person.identifier.orcid | 0000-0001-7191-6372 | |
| person.identifier.orcid | 0000-0002-7582-0893 | |
| person.identifier.rid | M-4137-2013 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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