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National survey of feasibility of NIV trials for management of children with bronchiolitis

dc.contributor.authorRosala Hallas, Anna
dc.contributor.authorJones, Ashley P
dc.contributor.authorBedson, Emma
dc.contributor.authorCompton, Vanessa
dc.contributor.authorFernandes, Ricardo M.
dc.contributor.authorLacy, David
dc.contributor.authorLyttle, Mark D
dc.contributor.authorPeak, Matthew
dc.contributor.authorThorburn, Kent
dc.contributor.authorvan Miert, Clare
dc.contributor.authorWoolfall, Kerry
dc.contributor.authorMcNamara, Paul S
dc.date.accessioned2021-04-08T15:25:25Z
dc.date.available2021-04-08T15:25:25Z
dc.date.issued2020
dc.description© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.pt_PT
dc.description.abstractBackground: Bronchiolitis is a major cause of admission to hospital in children. Non-invasive ventilation (NIV) support with continuous positive airway pressure (CPAP) or high-flow nasal cannula (HFNC) oxygen is routinely used for infants in the UK with bronchiolitis. Objective: To establish UK paediatric practice regarding management of bronchiolitis, and to explore issues pertinent to the design of a potential future randomised controlled trial of NIV. Design: Screening logs were completed in hospitals in England capturing information on paediatric bronchiolitis admissions. An online national survey of clinical practice was disseminated to healthcare professionals (HCPs) across the UK to ascertain current management strategies. Results: Screening logs captured data on 393 infants from 8 hospitals. Reasons for admission were most commonly respiratory distress and/or poor fluid intake. Oxygen was administered for 54% of admissions. Respiratory (CPAP and HFNC) and non-respiratory support administered varied considerably. The national survey was completed by 111 HCPs from 76 hospitals. Data were obtained on criteria used to commence and wean NIV, responsibilities for altering NIV settings, minimum training requirements for staff managing a child on NIV, and numbers of trained staff. Most centres were interested in and capable of running a trial of NIV, even out of normal office hours. Conclusions: Respiratory and non-respiratory management of bronchiolitis in UK centres varies widely. A trial of HFNC oxygen therapy in this group of patients is feasible and HCPs would be willing to randomise patients into such a trial. Future work should focus on defining trial eligibility criteria.pt_PT
dc.description.sponsorshipThis research was funded by the National Institute for Health Research (NIHR), Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-1014-35081).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ Paediatr Open. 2020 Oct 27;4(1):e000780.pt_PT
dc.identifier.doi10.1136/bmjpo-2020-000780pt_PT
dc.identifier.eissn2399-9772
dc.identifier.urihttp://hdl.handle.net/10451/47292
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Group Ltd.pt_PT
dc.relation.publisherversionhttps://bmjpaedsopen.bmj.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectNeonatologypt_PT
dc.subjectTherapeuticspt_PT
dc.titleNational survey of feasibility of NIV trials for management of children with bronchiolitispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPagee000780pt_PT
oaire.citation.titleBMJ Paediatrics Openpt_PT
oaire.citation.volume4pt_PT
person.familyNameFernandes
person.givenNameRicardo
person.identifier309018
person.identifier.orcid0000-0002-7253-6475
person.identifier.ridC-7501-2015
person.identifier.scopus-author-id24436565500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication862be38f-2247-424c-b26c-d3bdda4474be
relation.isAuthorOfPublication.latestForDiscovery862be38f-2247-424c-b26c-d3bdda4474be

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