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Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward

2021-03-12Journal article Open access
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dc.contributor.authorAmaral, Mariana
dc.contributor.authorCharmier, Adília J.
dc.contributor.authorAfonso, Ricardo A.
dc.contributor.authorCatarino, José
dc.contributor.authorFaísca, Pedro
dc.contributor.authorCarvalho, Lina
dc.contributor.authorAscensão, Lia
dc.contributor.authorCoelho, João M. P.
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorReis, Catarina Pinto
dc.date.accessioned2022-03-07T14:34:28Z
dc.date.available2022-03-07T14:34:28Z
dc.date.issued2021-03-12
dc.date.updated2022-02-21T09:20:16Z
dc.description.abstractAnaplastic thyroid carcinoma (ATC) is a very rare subtype of thyroid carcinoma and one of the most lethal malignancies. Poor prognosis is mainly associated with its undifferentiated nature, inoperability, and failing to respond to the typically used therapies for thyroid cancer. Photothermal Therapy (PTT) entails using light to increase tissues’ temperature, leading to hyperthermia-mediated cell death. Tumours are more susceptible to heat as they are unable to dissipate it. By using functionalized gold nanoparticles (AuNPs) that transform light energy into heat, it is possible to target the heat to the tumour. This study aims to formulate ATC-targeted AuNPs able to convert near-infrared light into heat, for PTT of ATC. Different AuNPs were synthetized and coated. Size, morphology, and surface plasmon resonances band were determined. The optimized coated-AuNPs were then functionalized with ligands to assess ATC’s specificity. Safety, efficacy, and selectivity were assessed in vitro. The formulations were deemed safe when not irradiated (>70% cell viability) and selective for ATC. However, when irradiated, holo-transferrin-AuNPs were the most cytotoxic (22% of cell viability). The biodistribution and safety of this formulation was assessed in vivo. Overall, this novel formulation appears to be a highly promising approach to evaluate in a very near future.pt_PT
dc.description.sponsorshipAuthors gratefully acknowledge Fundação para a Ciência e a Tecnologia (FCT) through projects UIDB/00645/2020, UIDB/04138/2020, PTDC/MED-QUI/31721/2017, UIDP/04138/2020 and Lusófona University, ULHT. Authors are also thankful to FCT/MCTES for the financial support to CESAM (UIDP/50017/2020, UIDB/50017/2020), through national funds. The authors are grateful to the Carla Vânia (iMedUlisboa) for her collaboration in HPLC analysis and Jesús Molpeceres (Faculty of Pharmacy, University of Alcalá) for donating the 8505C cell line.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAmaral M, Charmier AJ, Afonso RA, Catarino J, Faísca P, Carvalho L, et al. Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma: a step forward. Cancers [Internet]. 2021;13(6):1242. Disponível em: https://www.mdpi.com/2072-6694/13/6/1242pt_PT
dc.identifier.doi10.3390/cancers13061242pt_PT
dc.identifier.issn2072-6694
dc.identifier.slugcv-prod-2480543
dc.identifier.urihttp://hdl.handle.net/10451/51625
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationInstitute of <biophysics and Biomedical Engineering
dc.relationResearch Institute for Medicines
dc.relationNANOFORMULATED HYBRID MOLECULES FOR SPECIFIC TAREGETING MELANOMA METASTASIS
dc.relationResearch Institute for Medicines
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/13/6/1242pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnaplastic thyroid carcinomapt_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectNovel therapiespt_PT
dc.subjectGold nanoparticlespt_PT
dc.titleGold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forwardpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstitute of <biophysics and Biomedical Engineering
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleNANOFORMULATED HYBRID MOLECULES FOR SPECIFIC TAREGETING MELANOMA METASTASIS
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
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oaire.citation.issue6pt_PT
oaire.citation.startPage1242pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume13pt_PT
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person.familyNameMoura das Neves Amaral
person.familyNameJanuário Charmier
person.familyNameAfonso
person.familyNamede Jesus Guilherme Gaspar
person.familyNameBeco Pinto Reis
person.givenNameMariana
person.givenNameMaria Adilia
person.givenNameRicardo
person.givenNameMaria Manuela
person.givenNameAna Catarina
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person.identifier.orcid0000-0001-6814-7226
person.identifier.orcid0000-0002-1046-4031
person.identifier.ridD-5515-2019
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaidCE17-A249-4380 | Mariana Moura das Neves Amaral
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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