Publication
Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
| dc.contributor.author | Barbosa, R. R. | |
| dc.contributor.author | Silva, S. P. | |
| dc.contributor.author | Silva, S. L. | |
| dc.contributor.author | Melo, A. C. | |
| dc.contributor.author | Pedro, E. | |
| dc.contributor.author | Barbosa, M. P. | |
| dc.contributor.author | Pereira-Santos, M. C. | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-06-17T14:10:18Z | |
| dc.date.available | 2015-06-17T14:10:18Z | |
| dc.date.issued | 2011 | |
| dc.description | © 2011 Barbosa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | eng |
| dc.description.abstract | IL-17 is a pro-inflammatory cytokine implicated in autoimmune and inflammatory conditions. The development/survival of IL-17-producing CD4 T cells (Th17) share critical cues with B-cell differentiation and the circulating follicular T helper subset was recently shown to be enriched in Th17 cells able to help B-cell differentiation. We investigated a putative link between Th17-cell homeostasis and B cells by studying the Th17-cell compartment in primary B-cell immunodeficiencies. Common Variable Immunodeficiency Disorders (CVID), defined by defects in B-cell differentiation into plasma and memory B cells, are frequently associated with autoimmune and inflammatory manifestations but we found no relationship between these and Th17-cell frequency. In fact, CVID patients showed a decrease in Th17-cell frequency in parallel with the expansion of activated non-differentiated B cells (CD21(low)CD38(low)). Moreover, Congenital Agammaglobulinemia patients, lacking B cells due to impaired early B-cell development, had a severe reduction of circulating Th17 cells. Finally, we found a direct correlation in healthy individuals between circulating Th17-cell frequency and both switched-memory B cells and serum BAFF levels, a crucial cytokine for B-cell survival. Overall, our data support a relationship between Th17-cell homeostasis and B-cell maturation, with implications for the understanding of the pathogenesis of inflammatory/autoimmune diseases and the physiology of B-cell depleting therapies. | eng |
| dc.description.sponsorship | This work was supported by grants from ‘‘Fundação para a Ciência e a Tecnologia’’ (FCT) and by ‘‘Programa Operacional Ciência e Inovação 2010’’ (POCI2010) (R.M.M.V. and A.E.S.). R.R.B. received a PhD scholarship from FCT. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | eng |
| dc.identifier.citation | PLoS ONE August 2011 | Volume 6 | Issue 8 | e22848 | por |
| dc.identifier.issn | 1932-6203 | |
| dc.identifier.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022848 | |
| dc.identifier.uri | http://dx.doi.org/10.1371/journal.pone.0022848 | |
| dc.identifier.uri | http://hdl.handle.net/10451/18307 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Public Library of Science | eng |
| dc.title | Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation. | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | PLoS ONE | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |