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Local bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implants

2022Artigo científico Acesso aberto
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dc.contributor.authorJiang, Wei
dc.contributor.authorHou, Fushan
dc.contributor.authorGu, Yong
dc.contributor.authorSaiding, Qimanguli
dc.contributor.authorBao, Pingping
dc.contributor.authorTang, Jincheng
dc.contributor.authorWu, Liang
dc.contributor.authorChen, Chunmao
dc.contributor.authorShen, Cailiang
dc.contributor.authorPereira, Catarina Leite
dc.contributor.authorSarmento, Marco
dc.contributor.authorSarmento, Bruno
dc.contributor.authorCui, Wenguo
dc.contributor.authorChen, Liang
dc.date.accessioned2022-03-25T16:36:21Z
dc.date.available2022-03-25T16:36:21Z
dc.date.issued2022
dc.description© 2021 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)pt_PT
dc.description.abstractThe effective osteointegration of orthopedic implants is a key factor for the success of orthopedic surgery. However, local metabolic imbalance around implants under osteoporosis condition could jeopardize the fixation effect. Inspired by the bone structure and the composition around implants under osteoporosis condition, alendronate (A) was grafted onto methacryloyl hyaluronic acid (H) by activating the carboxyl group of methacryloyl hyaluronic acid to be bonded to inorganic calcium phosphate on trabecular bone, which is then integrated with aminated bioactive glass (AB) modified by oxidized dextran (O) for further adhesion to organic collagen on the trabecular bone. The hybrid hydrogel could be solidified on cancellous bone in situ under UV irradiation and exhibits dual adhesion to organic collagen and inorganic apatite, promoting osteointegration of orthopedic implants, resulting in firm stabilization of the implants in cancellous bone areas. In vitro, the hydrogel was evidenced to promote osteogenic differentiation of embryonic mouse osteoblast precursor cells (MC3T3-E1) as well as inhibit the receptor activator of nuclear factor-κ B ligand (RANKL)-induced osteoclast differentiation of macrophages, leading to the upregulation of osteogenic-related gene and protein expression. In a rat osteoporosis model, the bone-implant contact (BIC) of the hybrid hydrogel group increased by 2.77, which is directly linked to improved mechanical stability of the orthopedic implants. Overall, this organic-inorganic, dual-adhesive hydrogel could be a promising candidate for enhancing the stability of orthopedic implants under osteoporotic conditions.pt_PT
dc.description.sponsorshipThis work was supported by the National Key R&D Program of China (2020YFA0908200), National Natural Science Foundation of China (82120108017), Six talent peaks project in Jiangsu Province (WSW-018). This work was financed by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior in the framework of the project “Institute for Research and Innovation in Health Sciences” UID/BIM/04293/2019.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBioact Mater. 2021 Oct 19;12:169-184pt_PT
dc.identifier.doi10.1016/j.bioactmat.2021.10.017pt_PT
dc.identifier.eissn2452-199X
dc.identifier.urihttp://hdl.handle.net/10451/51990
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationInstitute for Research and Innovation in Health Sciences
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/bioactive-materialspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDual-functionalpt_PT
dc.subjectHydrogelspt_PT
dc.subjectOsseointegrationpt_PT
dc.subjectOsteoporosispt_PT
dc.subjectPeri-implantpt_PT
dc.titleLocal bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/BIM/04293/2019
oaire.awardTitleInstitute for Research and Innovation in Health Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F04293%2F2019/PT
oaire.citation.endPage184pt_PT
oaire.citation.startPage169pt_PT
oaire.citation.titleBioactive Materialspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCarmelino Cardoso Sarmento
person.givenNameMarco Aurélio
person.identifier.ciencia-id0A1B-33CF-B324
person.identifier.orcid0000-0003-0550-6417
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0b7cdf21-1714-4411-aa09-d26111e975d9
relation.isAuthorOfPublication.latestForDiscovery0b7cdf21-1714-4411-aa09-d26111e975d9
relation.isProjectOfPublicationbd95b51b-ea2b-4bb0-b7b9-b456896bb2e8
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