Publication
Glutaredoxin: Discovery, redox defense and much more
| dc.contributor.author | Ogata, Fernando T. | |
| dc.contributor.author | Branco, Vasco | |
| dc.contributor.author | Vale, Filipa F. | |
| dc.contributor.author | Coppo, Lucia | |
| dc.date.accessioned | 2022-04-13T15:49:28Z | |
| dc.date.available | 2022-04-13T15:49:28Z | |
| dc.date.issued | 2021-07 | |
| dc.date.updated | 2022-02-28T15:14:33Z | |
| dc.description.abstract | Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione, glutathione reductase, and NADPH, was first described as an electron donor for Ribonucleotide Reductase but, from the first discovery in E.coli, the Grx family has impressively grown, particularly in the last two decades. Several isoforms have been described in different organisms (from bacteria to humans) and with different functions. The unique characteristic of Grxs is their ability to catalyse glutathione-dependent redox regulation via glutathionylation, the conjugation of glutathione to a substrate, and its reverse reaction, deglutathionylation. Grxs have also recently been enrolled in iron sulphur cluster formation. These functions have been implied in various physiological and pathological conditions, from immune defense to neurodegeneration and cancer development thus making Grx a possible drug target. This review aims to give an overview on Grxs, starting by a phylogenetic analysis of vertebrate Grxs, followed by an analysis of the mechanisms of action, the specific characteristics of the different human isoforms and a discussion on aspects related to human physiology and diseases. | pt_PT |
| dc.description.sponsorship | LC, FTO and VB would like to dedicate this work to the memory of Professor Arne Holmgren, discoverer of glutaredoxin, a reference in redox research, a great mentor and storyteller. It was a privilege to work and learn from him. The authors want to thank also all the excellent scientists with whom Arne worked for their contribution to increases the knowledge about glutaredoxins. The authors thank Dr Colin Miller for proofreading the manuscript. LC was supported by the Swedish Cancer Society (961), the Swedish Research Council Medicine (13X-3529) and a grant from the Swedish Fulbright Commission (2020). VB and FFV are supported by iMed.ULisboa’s strategic project (UIDP/04138/2020; UIDB/04138/2020), financed by national funds from Fundação para a Ciência e Tecnologia, Portugal (FCT; www.fct.pt). VB is financed by national funds via Fundação para a Ciência e Tecnologia through Norma Transitória - DL57/2016/CP1376/CT002. FFV is financed by Fundação para a Ciência e Tecnologia through Assistant Researcher grant CEECIND/03023/2017. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Ogata FT, Branco V, Vale FF, Coppo L. Glutaredoxin: Discovery, redox defense and much more. Redox Biology [Internet]. 2021;43:101975. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S2213231721001233 | pt_PT |
| dc.identifier.doi | 10.1016/j.redox.2021.101975 | pt_PT |
| dc.identifier.eissn | 2213-2317 | |
| dc.identifier.slug | cv-prod-2773025 | |
| dc.identifier.uri | http://hdl.handle.net/10451/52340 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation | Research Institute for Medicines | |
| dc.relation | Research Institute for Medicines | |
| dc.relation | Not Available | |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2213231721001233 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Glutaredoxin | pt_PT |
| dc.subject | Redox regulation | pt_PT |
| dc.subject | Glutathionylation | pt_PT |
| dc.subject | Deglutathionylation | pt_PT |
| dc.subject | Iron homeostasis | pt_PT |
| dc.subject | Grxs phylogenetics | pt_PT |
| dc.title | Glutaredoxin: Discovery, redox defense and much more | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Research Institute for Medicines | |
| oaire.awardTitle | Research Institute for Medicines | |
| oaire.awardTitle | Not Available | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03023%2F2017%2FCP1476%2FCT0004/PT | |
| oaire.citation.startPage | 101975 | pt_PT |
| oaire.citation.title | Redox Biology | pt_PT |
| oaire.citation.volume | 43 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | CEEC IND 2017 | |
| person.familyName | Veloso Neves Branco | |
| person.familyName | Vale | |
| person.givenName | Vasco Rui | |
| person.givenName | Filipa | |
| person.identifier | C-1144-2014 | |
| person.identifier.ciencia-id | 671C-816B-F077 | |
| person.identifier.ciencia-id | 4718-00EF-4BF0 | |
| person.identifier.orcid | 0000-0002-0466-4934 | |
| person.identifier.orcid | 0000-0003-4635-0105 | |
| person.identifier.rid | C-3570-2013 | |
| person.identifier.scopus-author-id | 8271087300 | |
| person.identifier.scopus-author-id | 17136133700 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.cv.cienciaid | 4718-00EF-4BF0 | Ana Filipa Ferreira do Vale | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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