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NFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fate

2023-02Artigo científico Acesso aberto
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dc.contributor.authorRibeiro, Vanessa
dc.contributor.authorMartins, Susana G.
dc.contributor.authorLopes, Ana Sofia
dc.contributor.authorThorsteinsdottir, Solveig
dc.contributor.authorZilhão, Rita
dc.contributor.authorCarlos, Ana Rita
dc.date.accessioned2023-07-03T17:56:02Z
dc.date.available2023-07-03T17:56:02Z
dc.date.issued2023-02
dc.description.abstractNFIX, a member of the nuclear factor I (NFI) family of transcription factors, is known to be involved in muscle and central nervous system embryonic development. However, its expression in adults is limited. Similar to other developmental transcription factors, NFIX has been found to be altered in tumors, often promoting pro-tumorigenic functions, such as leading to proliferation, differentiation, and migration. However, some studies suggest that NFIX can also have a tumor suppressor role, indicating a complex and cancer-type dependent role of NFIX. This complexity may be linked to the multiple processes at play in regulating NFIX, which include transcriptional, post-transcriptional, and post-translational processes. Moreover, other features of NFIX, including its ability to interact with different NFI members to form homodimers or heterodimers, therefore allowing the transcription of different target genes, and its ability to sense oxidative stress, can also modulate its function. In this review, we examine different aspects of NFIX regulation, first in development and then in cancer, highlighting the important role of NFIX in oxidative stress and cell fate regulation in tumors. Moreover, we propose different mechanisms through which oxidative stress regulates NFIX transcription and function, underlining NFIX as a key factor for tumorigenesis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, V.; Martins, S.G.; Lopes, A.S.; Thorsteinsdóttir, S.; Zilhão, R.; Carlos, A.R. NFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fate. Int. J. Mol. Sci. 2023, 24, 4293. https://doi.org/10.3390/ijms24054293pt_PT
dc.identifier.doi10.3390/ijms24054293pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/58417
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT 2022.10813.BDpt_PT
dc.relationAssociation Française contre les Myopathies (AFM) Téléthon (contract no. 23049)pt_PT
dc.relationFCT, Portugal; CEECIND/01589/2017pt_PT
dc.relationL’Oréal Portugal Medals of Honor for Women in Science 2019pt_PT
dc.relationThe donor Henrique Meirelles who chose to support the MATRIHEALTH Project (CC1036)pt_PT
dc.relationFCT PTDC/BTM-ORG/1383/2020 e UIDB/00329/2020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleNFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fatept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.startPage4293pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume24pt_PT
person.familyNameThorsteinsdottir
person.familyNameZilhão
person.familyNameCabral Martins Carlos
person.givenNameSolveig
person.givenNameRita Maria Pulido Garcia Zilhão
person.givenNameAna Rita
person.identifierM-3561-2013
person.identifierN-1137-2016
person.identifier.ciencia-id6617-2213-FBDB
person.identifier.ciencia-idCF15-75FB-F490
person.identifier.ciencia-id2E10-CE9E-ECE4
person.identifier.orcid0000-0002-9018-3431
person.identifier.orcid0000-0002-1885-5432
person.identifier.orcid0000-0002-6953-1163
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication72f53b4c-978b-4ff0-b6bd-a042f259ab23
relation.isAuthorOfPublicationcfa9b9ca-8159-41ae-9857-f03e5502779a
relation.isAuthorOfPublicatione0046f8d-b782-457b-be1d-4d12656b502a
relation.isAuthorOfPublication.latestForDiscoverye0046f8d-b782-457b-be1d-4d12656b502a

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