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The inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprint

2019Artigo científico Acesso aberto
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dc.contributor.authorPremi, Enrico
dc.contributor.authorCalhoun, Vince D.
dc.contributor.authorDiano, Matteo
dc.contributor.authorGazzina, Stefano
dc.contributor.authorCosseddu, Maura
dc.contributor.authorAlberici, Antonella
dc.contributor.authorArchetti, Silvana
dc.contributor.authorPaternicò, Donata
dc.contributor.authorGasparotti, Roberto
dc.contributor.authorvan Swieten, John
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorSanchez-Valle, Raquel
dc.contributor.authorLaforce, Robert
dc.contributor.authorMoreno, Fermin
dc.contributor.authorSynofzik, Matthis
dc.contributor.authorGraff, Caroline
dc.contributor.authorMasellis, Mario
dc.contributor.authorTartaglia, Maria Carmela
dc.contributor.authorRowe, James
dc.contributor.authorVandenberghe, Rik
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorTagliavini, Fabrizio
dc.contributor.authorDe Mendonça, Alexandre
dc.contributor.authorSantana, Isabel
dc.contributor.authorButler, Chris
dc.contributor.authorDucharme, Simon
dc.contributor.authorGerhard, Alex
dc.contributor.authorDanek, Adrian
dc.contributor.authorLevin, Johannes
dc.contributor.authorOtto, Markus
dc.contributor.authorFrisoni, Giovanni
dc.contributor.authorCappa, Stefano
dc.contributor.authorSorbi, Sandro
dc.contributor.authorPadovani, Alessandro
dc.contributor.authorRohrer, Jonathan D.
dc.contributor.authorBorroni, Barbara
dc.contributor.authorAlmeida, Maria Rosario
dc.contributor.authorAnderl-Straub, Sarah
dc.contributor.authorAndersson, Christin
dc.contributor.authorAntonell, Anna
dc.contributor.authorArighi, Andrea
dc.contributor.authorBalasa, Mircea
dc.contributor.authorBarandiaran, Myriam
dc.contributor.authorBargalló, Nuria
dc.contributor.authorBartha, Robart
dc.contributor.authorBender, Benjamin
dc.contributor.authorBenussi, Luisa
dc.contributor.authorBinetti, Giuliano
dc.contributor.authorBlack, Sandra
dc.contributor.authorBocchetta, Martina
dc.contributor.authorBorrego-Ecija, Sergi
dc.contributor.authorBras, Jose
dc.contributor.authorBruffaerts, Rose
dc.contributor.authorCaroppo, Paola
dc.contributor.authorCash, David
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorConvery, Rhian
dc.contributor.authorCope, Thomas
dc.contributor.authorde Arriba, María
dc.contributor.authorDi Fede, Giuseppe
dc.contributor.authorDíaz, Zigor
dc.contributor.authorDick, Katrina M.
dc.contributor.authorDuro, Diana
dc.contributor.authorFenoglio, Chiara
dc.contributor.authorFerreira, Carlos
dc.contributor.authorFerreira, Catarina B.
dc.contributor.authorFlanagan, Toby
dc.contributor.authorFox, Nick
dc.contributor.authorFreedman, Morris
dc.contributor.authorFumagalli, Giorgio
dc.contributor.authorGabilondo, Alazne
dc.contributor.authorGauthier, Serge
dc.contributor.authorGhidoni, Roberta
dc.contributor.authorGiaccone, Giorgio
dc.contributor.authorGorostidi, Ana
dc.contributor.authorGreaves, Caroline
dc.contributor.authorGuerreiro, Rita
dc.contributor.authorHeller, Carolin
dc.contributor.authorHoegen, Tobias
dc.contributor.authorIndakoetxea, Begoña
dc.contributor.authorJelic, Vesna
dc.contributor.authorJiskoot, Lize
dc.contributor.authorKarnath, Hans-Otto
dc.contributor.authorKeren, Ron
dc.contributor.authorLeitão, Maria João
dc.contributor.authorLladó, Albert
dc.contributor.authorLombardi, Gemma
dc.contributor.authorLoosli, Sandra
dc.contributor.authorMaruta, Carolina
dc.contributor.authorMead, Simon
dc.contributor.authorMeeter, Lieke
dc.contributor.authorMiltenberger-Miltenyi, Gabriel
dc.contributor.authorvan Minkelen, Rick
dc.contributor.authorMitchell, Sara
dc.contributor.authorNacmias, Benedetta
dc.contributor.authorNeason, Mollie
dc.contributor.authorNicholas, Jennifer
dc.contributor.authorÖijerstedt, Linn
dc.contributor.authorOlives, Jaume
dc.contributor.authorPanman, Jessica
dc.contributor.authorPapma, Janne
dc.contributor.authorPatzig, Maximilian
dc.contributor.authorPievani, Michela
dc.contributor.authorPrioni, Sara
dc.contributor.authorPrix, Catharina
dc.contributor.authorRademakers, Rosa
dc.contributor.authorRedaelli, Veronica
dc.contributor.authorRittman, Tim
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorRosa-Neto, Pedro
dc.contributor.authorRossi, Giacomina
dc.contributor.authorRossor, Martin
dc.contributor.authorSantiago, Beatriz
dc.contributor.authorScarpini, Elio
dc.contributor.authorSemler, Elisa
dc.contributor.authorShafei, Rachelle
dc.contributor.authorShoesmith, Christen
dc.contributor.authorTábuas-Pereira, Miguel
dc.contributor.authorTainta, Mikel
dc.contributor.authorTang-Wai, David
dc.contributor.authorThomas, David L.
dc.contributor.authorThonberg, Hakan
dc.contributor.authorTimberlake, Carolyn
dc.contributor.authorTiraboschi, Pietro
dc.contributor.authorVandamme, Philip
dc.contributor.authorVandenbulcke, Mathieu
dc.contributor.authorVeldsman, Michele
dc.contributor.authorVerdelho, Ana
dc.contributor.authorVillanua, Jorge
dc.contributor.authorWarren, Jason
dc.contributor.authorWilke, Carlo
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorZulaica, Miren
dc.date.accessioned2022-04-18T15:52:27Z
dc.date.available2022-04-18T15:52:27Z
dc.date.issued2019
dc.description© 2019 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)pt_PT
dc.description.abstractFrontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. We considered 249 subjects with FTD-related pathogenetic mutations and 223 mutation non-carriers (HC). Dynamic connectivity was evaluated using independent component analysis and sliding-time window correlation to rs-fMRI data, and meta-state measures of global brain flexibility were extracted. Results show that presymptomatic FTD exhibits diminished dynamic fluidity, visiting less meta-states, shifting less often across them, and travelling through a narrowed meta-state distance, as compared to HC. Dynamic connectivity changes characterize preclinical FTD, arguing for the desynchronization of the inner fluctuations of the brain. These changes antedate clinical symptoms, and might represent an early signature of FTD to be used as a biomarker in clinical trials.pt_PT
dc.description.sponsorshipThis work was supported in part by grants from the NIH (R01REB020407, P20GM103472), NSF grant 1539067 and the Well- come Trust grant (JBR 103838).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeuroimage. 2019 Apr 1;189:645-654pt_PT
dc.identifier.doi10.1016/j.neuroimage.2019.01.080pt_PT
dc.identifier.eissn1095-9572
dc.identifier.issn1053-8119
dc.identifier.urihttp://hdl.handle.net/10451/52406
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/neuroimagept_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectC9orf72pt_PT
dc.subjectChronnectomept_PT
dc.subjectDynamic brain functional connectivitypt_PT
dc.subjectFrontotemporal dementiapt_PT
dc.subjectGranulinpt_PT
dc.subjectMicrotuble associate protein taupt_PT
dc.subjectMutationpt_PT
dc.subjectResting-state fMRIpt_PT
dc.titleThe inner fluctuations of the brain in presymptomatic frontotemporal dementia: the chronnectome fingerprintpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage654pt_PT
oaire.citation.startPage645pt_PT
oaire.citation.titleNeuroImagept_PT
oaire.citation.volume189pt_PT
person.familyNamede Mendonça
person.familyNameCastelo-Branco
person.familyNameMaruta
person.familyNameMiltenberger-Miltenyi
person.familyNameVerdelho
person.givenNameAlexandre
person.givenNameMiguel
person.givenNameCarolina
person.givenNameGabriel
person.givenNameAna
person.identifier351267
person.identifier.ciencia-id1615-41B4-0848
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person.identifier.ciencia-id4B1D-5F59-6221
person.identifier.ciencia-idAE16-3A8D-0392
person.identifier.ciencia-idFC14-938F-EBBD
person.identifier.orcid0000-0002-0488-1453
person.identifier.orcid0000-0003-4364-6373
person.identifier.orcid0000-0003-3359-379X
person.identifier.orcid0000-0003-0224-1281
person.identifier.orcid0000-0003-4945-4946
person.identifier.ridF-3866-2019
person.identifier.scopus-author-id7003320823
person.identifier.scopus-author-id6701423628
person.identifier.scopus-author-id35327513800
person.identifier.scopus-author-id6602902026
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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