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Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes

2021-02-10Journal article Open access
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dc.contributor.authorGameiro, Andreia
dc.contributor.authorNascimento, Catarina
dc.contributor.authorUrbano, Ana Catarina
dc.contributor.authorCorreia, Jorge Manuel de Jesus
dc.contributor.authorFerreira, Fernando
dc.date.accessioned2022-02-06T00:34:14Z
dc.date.available2022-02-06T00:34:14Z
dc.date.issued2021-02-10
dc.descriptionResearch Areas: Veterinary Sciencespt_PT
dc.description.abstractABSTRACT - Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight is a common condition in cat, the role of leptin and its receptor in feline mammary carcinoma remains unsettled. In this study, serum leptin and leptin receptor (ObR) levels were investigated in 58 cats with mammary carcinoma and compared with those of healthy animals, as were the expression levels of leptin and ObR in tumor tissues. The results showed that the Free Leptin Index is significantly decreased in cats with mammary carcinoma (p = 0.0006), particularly in those with luminal B and HER2-positive tumors, and that these animals also present significantly lower serum leptin levels (p < 0.0001 and p < 0.005, respectively). Interestingly, ulcerating tumors (p = 0.0005) and shorter disease-free survival (p = 0.0217) were associated to serum leptin levels above 4.17 pg/mL. In contrast, elevated serum ObR levels were found in all cats with mammary carcinoma (p < 0.0001), with levels above 16.89 ng/mL being associated with smaller tumors (p = 0.0118), estrogen receptor negative status (p = 0.0291) and increased serum levels of CTLA-4 (p = 0.0056), TNF-alpha (p = 0.0025), PD-1 (p = 0.0023), and PD-L1 (p = 0.0002). In tumor samples, leptin is overexpressed in luminal B and triple-negative carcinomas (p = 0.0046), whereas ObR is found to be overexpressed in luminal B tumors (p = 0.0425). Altogether, our results support the hypothesis that serum levels of leptin and ObR can be used as biomarkers of specific feline mammary carcinoma subtypes, and suggests the use of leptin antagonists as a therapeutic tool, reinforcing the utility of the cat as a cancer model.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGameiro A, Nascimento C, Urbano AC, Correia J, Ferreira F. 2021. Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes. Frontiers in Veterinary Science, 8:625147. Doi: 10.3389/fvets.2021.625147pt_PT
dc.identifier.doi10.3389/fvets.2021.625147pt_PT
dc.identifier.eissn2297-1769
dc.identifier.urihttp://hdl.handle.net/10400.5/23407
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media SApt_PT
dc.relationC00191rpt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relationDeveloping diagnostic tools for feline mammary carcinomas and improving chemotherapy based on HER2 and topoisometase status
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fvets.2021.625147/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFeline mammary carcinomapt_PT
dc.subjectLeptinpt_PT
dc.subjectLeptin receptorpt_PT
dc.subjectFree leptin indexpt_PT
dc.subjectBiomarkerspt_PT
dc.titleSerum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardTitleDeveloping diagnostic tools for feline mammary carcinomas and improving chemotherapy based on HER2 and topoisometase status
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT-EPI%2F3638%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F132260%2F2017/PT
oaire.citation.conferencePlaceLausanne, Switzerlandpt_PT
oaire.citation.titleFrontiers in Veterinary Sciencept_PT
oaire.citation.volumeVol.8:625147pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGameiro
person.familyNameGaspar do Nascimento
person.familyNameFernandes Urbano
person.familyNameJesus Correia
person.familyNameFerreira
person.givenNameAndreia
person.givenNameAna Catarina
person.givenNameAna Catarina
person.givenNameJorge Manuel
person.givenNameFernando António da Costa
person.identifier.ciencia-idB718-5199-AA36
person.identifier.ciencia-id2317-6BE3-E5F4
person.identifier.ciencia-id7311-54F2-A545
person.identifier.ciencia-idF81F-D7D4-57C5
person.identifier.orcid0000-0002-1602-3552
person.identifier.orcid0000-0002-1909-4540
person.identifier.orcid0000-0001-5765-576X
person.identifier.scopus-author-id7202364133
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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