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Does caffeine consumption modify cerebrospinal fluid amyloid-β levels in patients with Alzheimer’s disease?

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dc.contributor.authorTravassos, Maria
dc.contributor.authorSantana, Isabel
dc.contributor.authorBaldeiras, Inês
dc.contributor.authorTsolaki, Magda
dc.contributor.authorGkatzima, Olymbia
dc.contributor.authorSermin, Genc
dc.contributor.authorYener, Görsev G.
dc.contributor.authorSimonsen, Anja
dc.contributor.authorHasselbalch, Steen G.
dc.contributor.authorKapaki, Elisabeth
dc.contributor.authorMara, Bourbouli
dc.contributor.authorCunha, Rodrigo A.
dc.contributor.authorAgostinho, Paula
dc.contributor.authorBlennow, Kaj
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorMendes, Vera M.
dc.contributor.authorManadas, Bruno
dc.contributor.authorDe Mendonça, Alexandre
dc.date.accessioned2022-03-16T16:42:01Z
dc.date.available2022-03-16T16:42:01Z
dc.date.issued2015
dc.description© 2015 – IOS Press and the authors. All rights reservedpt_PT
dc.description.abstractCaffeine may be protective against Alzheimer's disease (AD) by modulating amyloid-β (Aβ) metabolic pathways. The present work aimed to study a possible association of caffeine consumption with the cerebrospinal fluid (CSF) biomarkers, particularly Aβ. The study included 88 patients with AD or mild cognitive impairment. The consumption of caffeine and theobromine was evaluated using a validated food questionnaire. Quantification of caffeine and main active metabolites was performed with liquid chromatography coupled to tandem mass spectrometry. The levels of A(1-42), total tau, and phosphorylated tau in the CSF were determined using sandwich ELISA methods and other Aβ species, Aβ(X-38), Aβ(X-40), and Aβ(X-42), with the MSD Aβ Triplex assay. The concentration of caffeine was 0.79±1.15 μg/mL in the CSF and 1.20±1.88 μg/mL in the plasma. No correlation was found between caffeine consumption and Aβ42 in the CSF. However, a significant positive correlation was found between the concentrations of theobromine, both in the CSF and in the plasma, with Aβ42 in the CSF. Theobromine in the CSF was positively correlated with the levels of other xanthines in the CSF, but not in the plasma, suggesting that it may be formed by central metabolic pathways. In conclusion, caffeine consumption does not modify the levels of CSF biomarkers, and does not require to be controlled for when measuring CSF biomarkers in a clinical setting. Since theobromine is associated with a favorable Aβ profile in the CSF, the possibility that it might have a protective role in AD should be further investigated.pt_PT
dc.description.sponsorshipPEst-C/SAU/LA0001/2013-2014 and The National Mass Spectrometry Network RNEM - REDE/1506/REM/2005pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Alzheimers Dis. 2015;47(4):1069-1078pt_PT
dc.identifier.doi10.3233/JAD-150374pt_PT
dc.identifier.eissn1875-8908
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/10451/51777
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIOS Presspt_PT
dc.relationPEst-C/SAU/LA0001/2013-2014pt_PT
dc.relationREDE/1506/REM/2005pt_PT
dc.relation.publisherversionhttps://content.iospress.com/journals/journal-of-alzheimers-disease/pt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectAmyloid-βpt_PT
dc.subjectBiomarkerspt_PT
dc.subjectCaffeinept_PT
dc.subjectCerebrospinal fluidpt_PT
dc.subjectMetabolismpt_PT
dc.subjectMild cognitive impairmentpt_PT
dc.subjectPhosphotaupt_PT
dc.subjectTheobrominept_PT
dc.subjectTotal taupt_PT
dc.titleDoes caffeine consumption modify cerebrospinal fluid amyloid-β levels in patients with Alzheimer’s disease?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1078pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1069pt_PT
oaire.citation.titleJournal of Alzheimer's Diseasept_PT
oaire.citation.volume47pt_PT
person.familyNamede Mendonça
person.givenNameAlexandre
person.identifier.ciencia-id1615-41B4-0848
person.identifier.orcid0000-0002-0488-1453
person.identifier.scopus-author-id7003320823
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication53ca3547-99ce-4b68-9330-7879a54c47b7
relation.isAuthorOfPublication.latestForDiscovery53ca3547-99ce-4b68-9330-7879a54c47b7

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