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Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012-2015)

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dc.contributor.authorSilva-Costa, Catarina
dc.contributor.authorBrito, Maria J.
dc.contributor.authorAguiar, Sandra I.
dc.contributor.authorLopes, Joana P.
dc.contributor.authorRamirez, Mário
dc.contributor.authorMelo Cristino, José
dc.date.accessioned2021-04-16T12:41:36Z
dc.date.available2021-04-16T12:41:36Z
dc.date.issued2019
dc.description© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractWe evaluated the impact of continued 13-valent pneumococcal conjugate vaccine (PCV13) use in the private market (uptake of 61%) in pediatric invasive pneumococcal disease (pIPD) in Portugal (2012-2015). The most frequently detected serotypes were: 3 (n = 32, 13.8%), 14 (n = 23, 9.9%), 1 (n = 23, 9.9%), 7F (n = 15, 6.4%), 19A (n = 13, 5.6%), 6B and 15B/C (both n = 12, 5.2%), and 24F, 10A and 12B (all with n = 10, 4.3%). Taken together, non-PCV13 serotypes were responsible for 42.2% of pIPD with a known serotype. The use of PCR to detect and serotype pneumococci in both pleural and cerebrospinal fluid samples contributed to 18.1% (n = 47) of all pIPD. Serotype 3 was mostly detected by PCR (n = 21/32, 65.6%) and resulted from a relevant number of vaccine failures. The incidence of pIPD varied in the different age groups but without a clear trend. There were no obvious declines of the incidence of pIPD due to serotypes included in any of the PCVs, and PCV13 serotypes still accounted for the majority of pIPD (57.8%). Our study indicates that a higher vaccination uptake may be necessary to realize the full benefits of PCVs, even after 15 years of moderate use, and highlights the importance of using molecular methods in pIPD surveillance, since these can lead to substantially increased case ascertainment and identification of particular serotypes as causes of pIPD.pt_PT
dc.description.sponsorshipThis work was partly supported by Fundação para a Ciência e a Tecnologia, Portugal (PTDC/DTP-EPI/1555/2014), LISBOA-01-0145-FEDER-007391, project cofunded by FEDER, through POR Lisboa 2020 - Programa Operacional Regional de Lisboa, PORTUGAL 2020 and Fundação para a Ciência e a Tecnologia, and an unrestricted Investigator initiated project from Pfizer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2019 Jan 9;9(1):6pt_PT
dc.identifier.doi10.1038/s41598-018-36799-xpt_PT
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10451/47452
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationLISBOA-01-0145-FEDER-007391pt_PT
dc.relationThe changing pneumococci: adapting to vaccination and transitioning between colonization and disease
dc.relation.publisherversionhttps://www.nature.com/srep/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleDominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012-2015)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/DTP-EPI/1555/2014
oaire.awardTitleThe changing pneumococci: adapting to vaccination and transitioning between colonization and disease
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F1555%2F2014/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage6pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameSilva Costa
person.familyNameAguiar
person.familyNameRamos de Almeida Ramirez
person.familyNameMelo Cristino
person.givenNameAna Catarina
person.givenNameSandra
person.givenNameMário Nuno
person.givenNameJosé
person.identifierA-3500-2009
person.identifierB-4993-2008
person.identifier.ciencia-id6517-D034-BADD
person.identifier.ciencia-id8E10-C536-8517
person.identifier.ciencia-id9C1C-F2A2-4226
person.identifier.ciencia-id871E-6AD6-F37C
person.identifier.orcid0000-0001-9681-0574
person.identifier.orcid0000-0002-3041-383X
person.identifier.orcid0000-0002-4084-6233
person.identifier.orcid0000-0001-8643-1722
person.identifier.ridH-3726-2013
person.identifier.scopus-author-id7201568476
person.identifier.scopus-author-id7004053640
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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