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IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

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dc.contributor.authorCunha, Cristina
dc.contributor.authorGonçalves, Samuel M.
dc.contributor.authorDuarte-Oliveira, Cláudio
dc.contributor.authorLeite, Luís
dc.contributor.authorLagrou, Katrien
dc.contributor.authorMarques, António
dc.contributor.authorLupiañez, Carmen B.
dc.contributor.authorMesquita, Inês
dc.contributor.authorGaifem, Joana
dc.contributor.authorBarbosa, Ana Margarida
dc.contributor.authorPinho Vaz, Carlos
dc.contributor.authorBranca, Rosa
dc.contributor.authorCampilho, Fernando
dc.contributor.authorFreitas, Fátima
dc.contributor.authorLigeiro, Dário
dc.contributor.authorLass-Flörl, Cornelia
dc.contributor.authorLöffler, Jürgen
dc.contributor.authorJurado, Manuel
dc.contributor.authorSaraiva, Margarida
dc.contributor.authorKurzai, Oliver
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorCastro, António G.
dc.contributor.authorSilvestre, Ricardo
dc.contributor.authorSainz, Juan
dc.contributor.authorMaertens, Johan A.
dc.contributor.authorTorrado, Egídio
dc.contributor.authorJacobsen, Ilse D.
dc.contributor.authorLacerda, João
dc.contributor.authorCampos, Jr, António
dc.contributor.authorCarvalho, Agostinho
dc.date.accessioned2022-11-23T15:53:51Z
dc.date.available2022-11-23T15:53:51Z
dc.date.issued2017
dc.description© 2017 American Academy of Allergy, Asthma & Immunologypt_PT
dc.description.abstractProinflammatory immune responses are critically required for antimicrobial host defenses; however, excessive inflammation has the potential to damage host tissues thereby paradoxically contributing to the progression of infection. A central negative regulator of inflammatory responses is IL-10, an immunosuppressive cytokine with a wide variety of functions across multiple cell types. Although the role of IL-10 during infection appears to vary for different microorganisms, a largely detrimental role has been attributed to this cytokine during fungal disease. Given the variable risk of infection and its outcome among patients with comparable predisposing factors, susceptibility to invasive aspergillosis (IA) is thought to rely largely on genetic predisposition. The initial investigation of genetic variability at the IL10 locus led to the identification of single nucleotide polymorphisms (SNPs) influencing its transcriptional activity; thus, IL-10 may be a reasonable candidate for the genetic regulation of susceptibility to IA in high-risk patients.pt_PT
dc.description.sponsorshipSupported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), the Fundação para a Ciência e Tecnologia (FCT) (contracts IF/00735/2014 to A.C., IF/01390/2014 to E.T., IF/00021/2014 to R.S., and SFRH/BPD/96176/2013 to C.C.), the Conselho de Reitores das Universidades Portuguesas (CRUP), Portugal (Ações Integradas Luso-Alemãs A-43/16), the Deutscher Akademischer Austauschdienst (DAAD) (project-ID 57212690), the Fondo de Investigaciones Sanitarias (Madrid, Spain) (grant #PI12/02688) and the ERA-NET PathoGenoMics (grant #0315900A).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Allergy Clin Immunol. 2017 Sep;140(3):867-870.e9pt_PT
dc.identifier.doi10.1016/j.jaci.2017.02.034pt_PT
dc.identifier.eissn1097-6825
dc.identifier.issn0091-6749
dc.identifier.urihttp://hdl.handle.net/10451/55225
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationNORTE-01-0145-FEDER-000013pt_PT
dc.relationIF/00735/2014pt_PT
dc.relationIF/01390/2014pt_PT
dc.relationIF/00021/2014pt_PT
dc.relationTHE ROLE OF INFLAMMASOME ACTIVATION IN HOST IMMUNITY TO FUNGAL INFECTION - The inflammasome-microbiota interplay in antifungal immunity
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunologypt_PT
dc.titleIL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTHE ROLE OF INFLAMMASOME ACTIVATION IN HOST IMMUNITY TO FUNGAL INFECTION - The inflammasome-microbiota interplay in antifungal immunity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F96176%2F2013/PT
oaire.citation.endPage870.e9pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage867pt_PT
oaire.citation.titleJournal of Allergy and Clinical Immunologypt_PT
oaire.citation.volume140pt_PT
person.familyNameLacerda
person.givenNameJoão
person.identifier559297
person.identifier.ciencia-id6412-2B63-2364
person.identifier.orcid0000-0003-1351-2809
person.identifier.scopus-author-id6603819609
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationafb302b1-8272-48de-b347-cb5b54a0a3da
relation.isAuthorOfPublication.latestForDiscoveryafb302b1-8272-48de-b347-cb5b54a0a3da
relation.isProjectOfPublicationf53289b8-69d0-42bb-b3a1-e7533a1d0951
relation.isProjectOfPublication.latestForDiscoveryf53289b8-69d0-42bb-b3a1-e7533a1d0951

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