Publication
Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells
| dc.contributor.author | Madureira, AM | |
| dc.contributor.author | Spengler, G | |
| dc.contributor.author | Molnar, A | |
| dc.contributor.author | Varga, A | |
| dc.contributor.author | Molnar, J | |
| dc.contributor.author | Abreu, PM | |
| dc.contributor.author | Ferreira, MJU | |
| dc.date.accessioned | 2015-12-30T10:17:06Z | |
| dc.date.available | 2015-12-30T10:17:06Z | |
| dc.date.issued | 2004 | |
| dc.description.abstract | The ability of fifteen cycloartanes, isolated from Euphorbia species, to reverse multidrug resistance (MDR) and apoptosis induction in L5178Y mouse lymphoma cells, including its multidrug-resistant subline, was studied by flow cytometry. Reversion of MDR was investigated using a standard functional assay with rhodamine 123 as a fluorescent substrate analogue. For the evaluation of apoptosis, the cells were stained with FITC-labeled annexin V and propidium iodide. The majority of the compounds were able to reverse MDR of the tested human MDR1 gene-transfected mouse lymphoma cells. Some of the compounds were able to induce moderate apoptosis in the PAR cell line, but this effect was less effective on multidrug-resistant cells. The results indicate that cycloartanes can be substrates of ABC transporters, which might compete with certain anticancer chemotherapeutics. | |
| dc.format | application/pdf | |
| dc.identifier.citation | ANTICANCER RESEARCH. - Vol. 24, n. 2B (MAR-APR 2004), p. 859-864 | |
| dc.identifier.issn | 0250-7005 | |
| dc.identifier.uri | http://hdl.handle.net/10451/20927 | |
| dc.language.iso | eng | |
| dc.publisher | INT INST ANTICANCER RESEARCH | |
| dc.subject | Oncology | |
| dc.title | Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 864 | por |
| oaire.citation.startPage | 859 | por |
| oaire.citation.title | ANTICANCER RESEARCH | por |
| oaire.citation.volume | Vol. 24 | por |
| rcaap.rights | restrictedAccess | |
| rcaap.type | article |