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Role of adenosine in epilepsy and seizures

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dc.contributor.authorTescarollo, Fabio C.
dc.contributor.authorRombo, Diogo M.
dc.contributor.authorDeLiberto, Lindsay K.
dc.contributor.authorFedele, Denise E.
dc.contributor.authorAlharfoush, Enmar
dc.contributor.authorTomé, Ângelo R.
dc.contributor.authorCunha, Rodrigo A.
dc.contributor.authorSebastião, Ana M
dc.contributor.authorBoison, Detlev
dc.date.accessioned2021-02-18T16:24:47Z
dc.date.available2021-02-18T16:24:47Z
dc.date.issued2020
dc.description© Mary Ann Liebert, Inc.pt_PT
dc.description.abstractAdenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure. However, within the context of epilepsy, adenosine plays a wide spectrum of different roles. It not only controls seizures (ictogenesis), but also plays a major role in processes that turn a normal brain into an epileptic brain (epileptogenesis). It is involved in the control of abnormal synaptic plasticity and neurodegeneration and plays a major role in the expression of comorbid symptoms and complications of epilepsy, such as sudden unexpected death in epilepsy (SUDEP). Given the important role of adenosine in epilepsy, therapeutic strategies are in development with the goal to utilize adenosine augmentation not only for the suppression of seizures but also for disease modification and epilepsy prevention, as well as strategies to block adenosine A2A receptor overfunction associated with neurodegeneration. This review provides a comprehensive overview of the role of adenosine in epilepsy.pt_PT
dc.description.sponsorshipThe authors acknowledge grant support from the National Institutes of Health to D.B. (NINDS: NS103740, NS065957); support to A.M.S. by LISBOA-01-0145-FEDER-007391, project cofunded by Fundo Europeu Para o Desenvolvimento Regional through POR Lisboa 2020 (Programa Operacional Regional de Lisboa) from PORTUGAL 2020 and Fundação para a Ciência e Tecnologia (FCT), by an FCT project (PTDC/MED-FAR/30933/2017) and by Twinning action (SynaNet) from the EU H2020 programme (project number: 692340); and support to R.A.C. and A.R.T. by Fundacion LaCaixa (LCF/PR/HP17/52190001), Centro 2020 (CENTRO-01-0145-FEDER-000008: BrainHealth 2020 and CENTRO-01-0246-FEDER-000010) and FCT (POCI-01-0145-FEDER-03127).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Caffeine Adenosine Res. 2020 Jun 1;10(2):45-60pt_PT
dc.identifier.doi10.1089/caff.2019.0022pt_PT
dc.identifier.eissn2573-3400
dc.identifier.issn2573-3397
dc.identifier.urihttp://hdl.handle.net/10451/46426
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebert, Inc.pt_PT
dc.relationLISBOA-01-0145-FEDER-007391pt_PT
dc.relationNS103740pt_PT
dc.relationNS065957pt_PT
dc.relationIn the search of the synaptic mechanism operated by a novel selective antiepileptic drug
dc.relationNeurologic and Psychiatric Disorders: from synapses to networks
dc.relationCENTRO-01-0145-FEDER-000008pt_PT
dc.relationCENTRO-01-0246-FEDER-000010pt_PT
dc.relationPOCI-01-0145-FEDER-03127pt_PT
dc.relation.publisherversionhttps://home.liebertpub.com/publications/journal-of-caffeine-and-adenosine-research/388/pt_PT
dc.subjectAdenosinept_PT
dc.subjectAdenosine receptorspt_PT
dc.subjectAdenosine kinasept_PT
dc.subjectEpilepsypt_PT
dc.subjectSeizurept_PT
dc.subjectEpileptogenesispt_PT
dc.titleRole of adenosine in epilepsy and seizurespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIn the search of the synaptic mechanism operated by a novel selective antiepileptic drug
oaire.awardTitleNeurologic and Psychiatric Disorders: from synapses to networks
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-FAR%2F30933%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/692340/EU
oaire.citation.endPage60pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage45pt_PT
oaire.citation.titleJournal of Caffeine and Adenosine Researchpt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamH2020
person.familyNameRombo
person.familyNameSebastião
person.givenNameDiogo
person.givenNameAna M
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.orcid0000-0002-9922-7381
person.identifier.orcid0000-0001-9030-6115
person.identifier.scopus-author-id7004409879
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication304abd7f-071b-4447-a8a3-4aa5f0547141
relation.isAuthorOfPublication.latestForDiscovery8814f5da-e3f7-4b74-af11-09616eecdee1
relation.isProjectOfPublication7027027e-87f3-442e-9bdc-9fadad40a229
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