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Development of bioactive films based on chitosan and Cynara cardunculus leaves extracts for wound dressings

2020Journal article Open access
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dc.contributor.authorBrás, Teresa
dc.contributor.authorRosa, Daniela
dc.contributor.authorGonçalves, Ana C.
dc.contributor.authorGomes, Andreia C.
dc.contributor.authorDelgado Alves, Vitor
dc.contributor.authorCrespo, João G.
dc.contributor.authorDuarte, Maria F.
dc.contributor.authorNeves, Luísa A.
dc.date.accessioned2021-09-29T11:23:36Z
dc.date.available2021-09-29T11:23:36Z
dc.date.issued2020
dc.description.abstractThe development of natural based, effective and protective wound dressings associated to local treatment applied on chronic wounds, represents a major challenge nowadays. In this work chitosan-based films were prepared with different concentrations of ethanolic ultrasound assisted extracts from Cynara cardunculus leaves (EtPUAE). The physico-chemical film properties revealed that extract incorporation influences the volumetric swelling capacity and mechanical properties of the films, leading to materials with a lower fluid absorption capacity and more fragile. However, no impact was detected on the thermal properties of the films, as well as on their dense structure characterized by Scanning Electronic Microscopy (SEM) analysis. Biological screening of chitosan-based films show that chitosan with a 1% (w/w) and a 5% (w/w) EtPUAE loading did not induce cytotoxicity on normal human skin fibroblasts (Bj5-ta cell line), mainly attributed to cynaropicrin (extract key active compound) present in the film below its IC50 value. Nevertheless, chitosan-based films with 5% (w/w) EtPUAE presented an interesting anti-inflammatory activity. Bj5-ta cells stimulated with liposaccharides (LPS), presented a reduction of 86% on IL-6 cytokine levels, after exposure to chitosan with 5% EtPUAE film extract. The results obtained in this study open up the possibility of successfully using chitosan films doped with EtPUAE for development of chronic wound dressings, with the advantage of using naturally-sourced materials with anti-inflammatory activitypt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInternational Journal of Biological Macromolecules Volume 163, 15 November 2020, Pages 1707-1718pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.ijbiomac.2020.09.109pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/22096
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUID/AGR/04129/2020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectchitosan filmspt_PT
dc.subjectcynara cardunculus extractspt_PT
dc.subjectcynaropicrinpt_PT
dc.subjectwound dressingpt_PT
dc.subjectskin inflammationpt_PT
dc.titleDevelopment of bioactive films based on chitosan and Cynara cardunculus leaves extracts for wound dressingspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157669/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157632/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/154698/PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameDelgado Alves
person.givenNameVitor
person.identifier1916677
person.identifier.ciencia-id2E1E-6918-4DB3
person.identifier.orcid0000-0002-4117-5582
person.identifier.scopus-author-id24536716000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8d1a8489-8789-4569-89e2-0bade23dd945
relation.isAuthorOfPublication.latestForDiscovery8d1a8489-8789-4569-89e2-0bade23dd945
relation.isProjectOfPublicationee84b345-fd68-4cd9-917c-2548124d2f47
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